| Cat. No. |
Product Name |
Information |
| PC-49422 |
Transthyretin stabilizer M-23
Transthyretin stabilizer
|
Transthyretin stabilizer M-23 is a potent transthyretin (TTR) stabilizer with binding Kd of 6 nM (WT-TTR), enhances TTR tetramer stability both in vitro and in whole serume. |
| PC-49419 |
KIO-100
DHODH inhibitor
|
KIO-100 (PP-001) is a novel potent, specific small molecule inhibitor of DHODH with IC50 of <4 nM, 150-fold higher potency than leflunomide (IC50 of 650 nM). |
| PC-49413 |
UNC-CA157
COQ8A inhibitor
|
UNC-CA157 is a selective small molecule inhibitor of the archetypal UbiB member COQ8A with IC50 of 580 nM, shows clear preference for COQ8A over COQ8B. |
| PC-49409 |
ZHAWOC8697
SENP inhibitor
|
ZHAWOC8697 is a small molecule dual inhibitor of sentrin-specific protease SENP1 and SENP2 with IC50 of 8.6 and 2.3 uM, respectively, a valuable tool for the study of SUMOylation processes. |
| PC-49405 |
PITPNM3 inhibitor C8018-7840
PITPNM3 inhibitor
|
PITPNM3 inhibitor C8018-7840 is a selective small molecular inhibitor of oncogenic membrane-associated phosphatidylinositol transfer protein 3 (PITPNM3) with binding KD of 500 nM, inhibits CCL18-PITPNM3 signaling mediated cell migration and invasion. |
| PC-49404 |
SMC-21598
CCL8 inhibitor
|
SMC-21598 is a specific small molecule CCL18 antagonist, binds with high-afnity on the CCL18 protein in 1:1 stoichiometry with ITC KD value of 600 nM, blocks the binding of CCL18 with its receptor PITPNM3. |
| PC-49403 |
cGAS inhibitor 3
cGAS inhibitor
|
cGAS inhibitor 3 is a potent, selective and covalent inhibitor of cyclic GMP-AMP synthase (cGAS) with cellular IC50 of 0.51 uM. |
| PC-49389 |
BAY-069
BCAT inhibitor
|
BAY-069 (BAY069) is a potent, selective branched-chain amino acid transaminase BCAT1/2 inhibitor with IC50 of 31/153 nM, respectively. |
| PC-49387 |
Meprin α inhibitor 10d
Meprin α inhibitor
|
Meprin α inhibitor 10d (Compound 10d) is a potent specific Meprin α inhibitor with IC50 of 160 nM, less potent for meprin β (IC50=2,950 nM). |
| PC-49386 |
S9-A13
SLC26A9 inhibitor
|
S9-A13 is a highly potent and specific inhibitor of SLC26A9, potently inhibits SLC26A9-mediated Cl−/I− and Cl−/SCN− exchange activities with IC50 of 90.9 and 171.5 nM, respectively. |
| PC-49384 |
DKC1125
KITENIN inhibitor
|
DKC1125 is a small molecule KSRP-binding compound that specifically inhibits the oncogenic KITENIN complex, suppresses distant metastasis of colorectal cancer (CRC). |
| PC-49381 |
Aldometanib
Aldolase inhibitor
|
Aldometanib (LXY-05-029) is a selective small molecule inhibitor of aldolase (ALDOA) with IC50 of 50 uM in in vitro enzymatic assays, Aldometanib (5 nM) is sufficient to activate AMPK inside cells. |
