| Cat. No. |
Product Name |
Information |
| PC-21350 |
IP-DNQ
NQO1 inhibitor
|
IP-DNQ (Isopentyl-deoxynboquinone) is a small molecule that selectively kills pancreatic ductal adenocarcinoma cells in an NQO1-dependent manner. |
| PC-21347 |
Karyostatin 1A
Importin β inhibitor
|
Karyostatin 1A is a small molecule inhibitor of importin beta with binding affinity (Kd=0.3 uM), selectively inhibits the importin α/β pathway. |
| PC-21343 |
GPR101 agonist AA-14
GPR101 agonist
|
GPR101 agonist AA-14 is a specific small molecule agonist of GPR101 with EC50 of 0.37 uM, 0.88 uM and 2.14 uM in activating Gs, Gq or β-arrestin2 assays respectively. |
| PC-21339 |
Butaselen
TrxR1 inhibitor
|
Butaselen (BS1801) is a small molecule inhibitor of Thioredoxin reductase 1 (TrxR1) with anti-tumor activity, inhibits the growth of various human cancer cell lines. |
| PC-21334 |
Aster inhibitor AI-3d
Asters inhibitor
|
Aster inhibitor AI-3d is a potent, selective small molecule inhibitor of Aster proteins (encoded by the Gramd1a-c genes) with IC50 of 0.11 μM, 0.06 μM and 0.71 uM for Aster-A, Aster-B, and Aster-C, respectively. |
| PC-21318 |
PSB-22034
MRGPRX4 agonist
|
PSB-22034 is a potent, selective agonist of MAS-related Gq protein-coupled receptor X4 (MRGPRX4) with EC50 of 11.2 nM/32.0 nM in Ca2+ assay/β-arrestin assays (variant 83S), respectively. |
| PC-21313 |
HsClpP activator ZK53
HsClpP activator
|
HsClpP activator ZK53 is a potent, selective activator of mitochondrial caseinolytic protease P (HsClpP) with EC50 of 0.22 uM in FI-based protease activity assays, inactive toward bacterial ClpP proteins. |
| PC-21299 |
2-MPPA
GCP-II Inhibitor
|
2-MPPA (GPI-5693) is a potent, selective and orally active glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor with IC50 of 90 nM. |
| PC-21294 |
NVS1.1
eRF1 inhibitor
|
NVS1.1 is a potent readthrough promoter, promotes the rapid and specific degradation of eukaryotic release factor 1 (eRF1) and restores functional full-length proteins in cystic fibrosis and Hurler disease models. |
| PC-21278 |
MSN-CD44 inhibitor 2
CD44-MSN inhibitor
|
MSN-CD44 inhibitor 2 is a small molecule FERM domain protein-protein interaction inhibitor for moesin (MSN) and CD44 with SPR KD of 0.7 uM, is a potent inhibitor of CD44-MSN interaction in live cells with IC50 of 200 nM. |
| PC-21277 |
MSN-CD44 inhibitor 1
CD44-MSN inhibitor
|
MSN-CD44 inhibitor 1 is a small molecule FERM domain protein-protein interaction inhibitor for moesin (MSN) and CD44 with SPR KD of 4.2 uM, is a potent inhibitor of CD44-MSN interaction in live cells with IC50 of 600 nM. |
| PC-21274 |
ARUK2007145
PI5P4Kα/γ inhibitor
|
ARUK2007145 is a potent, selective and cell-active PI5P4Kα/γ dual inhibitor with pIC50 of 7.3/8.1, resepctively, shows no activity against PI5P4Kβ. |
