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Chemical Structure : Z839878730
Catalog No.: PC-20112Not For Human Use, Lab Use Only.
Z839878730 (KK-LC-1 inhibitor Z8) is a small moelcuel compound targeting KK-LC-1, which is significantly highly expressed in triple-negative breast cancer tissues than in normal breast tissues.
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Z839878730 (KK-LC-1 inhibitor Z8) is a small moelcuel compound targeting KK-LC-1, which is significantly highly expressed in triple-negative breast cancer tissues than in normal breast tissues.
Z839878730 (KK-LC-1 inhibitor Z8) exhibits good proliferation inhibition ability in triple-negative breast cancer cell lines with EC50 value of 9.7 µM and 13.67 µM for MDA-MB-231 and MDA-MB-468 cells, respectively, displays poor antiproliferation effect against low KK-LC-1 expression cells, such as MCF7, SKBR3, and MDA-MB-231/KD cells.
Z839878730 (KK-LC-1 inhibitor Z8) significantly inhibits the proliferation, scratch healing, invasion, and migration of MDA-MB-468 cells, also significantly increased the apoptosis ratio and arrested the cell cycle in the G0-G1 phase.
Z839878730 (KK-LC-1 inhibitor Z8) has little tumor-killing effect on human normal mammary epithelial cells MCF10A.
Z839878730 (KK-LC-1 inhibitor Z8) can inhibit the malignant biological behaviors of triple-negative breast cancer cells by MAL2/MUC1-C/PI3K/AKT/mTOR pathway.
| M.Wt | 392.52 | |
| Formula | C22H24N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xudong Zhu, et al. J Transl Med. 2023 Mar 9;21(1):184.
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