Z839878730 (KK-LC-1 inhibitor Z8) is a small moelcuel compound targeting KK-LC-1, which is significantly highly expressed in triple-negative breast cancer tissues than in normal breast tissues.
Z839878730 (KK-LC-1 inhibitor Z8) exhibits good proliferation inhibition ability in triple-negative breast cancer cell lines with EC50 value of 9.7 µM and 13.67 µM for MDA-MB-231 and MDA-MB-468 cells, respectively, displays poor antiproliferation effect against low KK-LC-1 expression cells, such as MCF7, SKBR3, and MDA-MB-231/KD cells.
Z839878730 (KK-LC-1 inhibitor Z8) significantly inhibits the proliferation, scratch healing, invasion, and migration of MDA-MB-468 cells, also significantly increased the apoptosis ratio and arrested the cell cycle in the G0-G1 phase.
Z839878730 (KK-LC-1 inhibitor Z8) has little tumor-killing effect on human normal mammary epithelial cells MCF10A.
Z839878730 (KK-LC-1 inhibitor Z8) can inhibit the malignant biological behaviors of triple-negative breast cancer cells by MAL2/MUC1-C/PI3K/AKT/mTOR pathway.