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(R)-SKBG-1

Chemical Structure : (R)-SKBG-1

CAS No.: 2955634-67-8

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(R)-SKBG-1

Catalog No.: PC-20048Not For Human Use, Lab Use Only.

(R)-SKBG-1 is a covalent small molecule ligand of RNA-binding protein NONO, engages NONO Cys145 and suppress an array of cancer-relevant genes and impair cancer cell proliferation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    (R)-SKBG-1 is a covalent small molecule ligand of RNA-binding protein NONO, engages NONO Cys145 and suppress an array of cancer-relevant genes and impair cancer cell proliferation.
    (R)-SKBG-1 promoted NONO accumulation in nuclear foci and stabilized NONO-RNA interactions.
    Reintroduction of wild-type NONO, but not a C145S mutant, restored (R)-SKBG-1 sensitivity in NONO-disrupted cells.

    Physicochemical Properties

    M.Wt 495.98
    Formula C22H26ClN3O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-4-(2-chloroacetyl)-N-(4-methoxybenzyl)-1-((4-methoxyphenyl)sulfonyl)piperazine-2-carboxamide

    References

    1. Kathman SG, et al. Nat Chem Biol. 2023 Mar 2. doi: 10.1038/s41589-023-01270-0.

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