Catalog No.: PC-20048Not For Human Use, Lab Use Only.
(R)-SKBG-1 is a covalent small molecule ligand of RNA-binding protein NONO, engages NONO Cys145 and suppress an array of cancer-relevant genes and impair cancer cell proliferation.
(R)-SKBG-1 is a covalent small molecule ligand of RNA-binding protein NONO, engages NONO Cys145 and suppress an array of cancer-relevant genes and impair cancer cell proliferation.
(R)-SKBG-1 promoted NONO accumulation in nuclear foci and stabilized NONO-RNA interactions.
Reintroduction of wild-type NONO, but not a C145S mutant, restored (R)-SKBG-1 sensitivity in NONO-disrupted cells.
