Nizubaglustat (AZ-3102) | GCS inhibitor

Chemical Structure : Nizubaglustat

Nizubaglustat (AZ-3102, AZ3102)

Catalog No.: PC-20061Not For Human Use, Lab Use Only.

Nizubaglustat (AZ-3102) is a potent, selective inhibitor of glucosylceramide synthase (GCS) with IC50 of 25 nM, inhibits acid glucosylceramidase (GBA1) and neutral glucosylceramidase (GBA2) with IC50 of 200 and 0.08 nM, respectively.

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Biological Activity

Nizubaglustat (AZ-3102) is a potent, selective inhibitor of glucosylceramide synthase (GCS) with IC50 of 25 nM, inhibits acid glucosylceramidase (GBA1) and neutral glucosylceramidase (GBA2) with IC50 of 200 and 0.08 nM, respectively.

Physicochemical Properties

M.Wt	433.52
Formula	C24H32FNO5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4R,5S)-1-(5-((2-fluoro-[1,1'-biphenyl]-4-yl)methoxy)pentyl)-2-(hydroxymethyl)piperidine-3,4,5-triol

References

1. Amar T Ghisaidoobe, et al. J Med Chem. 2014 Nov 13;57(21):9096-104.

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Nizubaglustat (AZ-3102, AZ3102)

Biological Activity

Physicochemical Properties

References

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