GBT601 (Osivelotor, GBT021601)

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Chemical Structure : GBT601

Catalog No.: PC-20064Not For Human Use, Lab Use Only.

GBT601 (Osivelotor, GBT021601) is an oral, small molecule, next-generation sickle hemoglobin (HbS) polymerization inhibitor, increases hemoglobin-oxygen (Hb-O2) affinity and stabilizes Hb in the oxy-hemoglobin (oxyHb) state, thereby inhibiting polymerization of HbS in RBCs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GBT601 (Osivelotor, GBT021601) is an oral, small molecule, next-generation sickle hemoglobin (HbS) polymerization inhibitor, increases hemoglobin-oxygen (Hb-O2) affinity and stabilizes Hb in the oxy-hemoglobin (oxyHb) state, thereby inhibiting polymerization of HbS in RBCs.

Physicochemical Properties

M.Wt	386.40
Formula	C20H22N2O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Hydroxy-6-[[(3S)-4-[[2-(2-hydroxyethyl)-3-pyridinyl]carbonyl]-3-morpholinyl]methoxy]benzaldehyde

References

1. R. Clark Clark Brown, et al. Blood. Volume 138, Supplement 1, 23 November 2021, Page 3099

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