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GBT601

Chemical Structure : GBT601

CAS No.: 2417955-18-9

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GBT601 (Osivelotor, GBT021601)

Catalog No.: PC-20064Not For Human Use, Lab Use Only.

GBT601 (Osivelotor, GBT021601) is an oral, small molecule, next-generation sickle hemoglobin (HbS) polymerization inhibitor, increases hemoglobin-oxygen (Hb-O2) affinity and stabilizes Hb in the oxy-hemoglobin (oxyHb) state, thereby inhibiting polymerization of HbS in RBCs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GBT601 (Osivelotor, GBT021601) is an oral, small molecule, next-generation sickle hemoglobin (HbS) polymerization inhibitor, increases hemoglobin-oxygen (Hb-O2) affinity and stabilizes Hb in the oxy-hemoglobin (oxyHb) state, thereby inhibiting polymerization of HbS in RBCs.

    Physicochemical Properties

    M.Wt 386.40
    Formula C20H22N2O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-Hydroxy-6-[[(3S)-4-[[2-(2-hydroxyethyl)-3-pyridinyl]carbonyl]-3-morpholinyl]methoxy]benzaldehyde

    References

    1. R. Clark Clark Brown, et al. Blood. Volume 138, Supplement 1, 23 November 2021, Page 3099

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