| Cat. No. |
Product Name |
Information |
| PC-27804 |
BSH-IN-1
BSH inhibitor
|
BSH-IN-1 is a potent and covalent inhibitor of gut bacterial bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively. |
| PC-27803 |
BSH inhibitor GR-7
BSH inhibitor
|
BSH inhibitor GR-7 (Gut restricted-7) is a potent, specific, covalent inhibitor of gut bacterial bile salt hydrolase (BSH) with IC50 of 237-1070 nM. |
| PC-27800 |
SMALS-329
LKB1 activator
|
SMALS-329 is a small-molecule activator of liver kinase B1 (LKB1, STK11) via pseudokinase STE20-related kinase adapter protein (STRAD) with EC50 of 8.5 uM (activation 541%), binds ATP pocket of STRADα to activate LKB1. |
| PC-27728 |
UCB-J
SV2A modulator
|
UCB-J is a selective allosteric modulator of synaptic vesicle protein 2A (SV2A) with pIC50 of 8.15 and 7.6 human and rat SV2A respectively. |
| PC-27727 |
ABBV-552
SV2A modulator
|
ABBV-552 (SDI-118) is a high-affinity, orally available positive synaptic vesicle glycoprotein 2 A (SV2A) modulator with IC50 of 13 nM in in vitro radioligand binding study using human recombinant SV2A (hSV2A). |
| PC-27712 |
XJ-4-85
PFKL activator
|
XJ-4-85 is a highly selective, covalent, allosteric phosphofructokinase-1 liver type (PFKL) activator with EC50 of 342.3 nM in substrate assays (4h), releases carnitine palmitoyltransferase 2 (CPT2) inhibitor destabilize cancer cell metabolism. |
| PC-27709 |
STK947495
NPM1 oligomerization inhibitor
|
STK947495 is a small-molecule modulator of Nucleophosmin 1 (NPM1) oligomerization, promotes dissociation of NPM1 oligomers, reduces NPM1 oligomerization in both lysate-based split luciferase and biochemical assays. |
| PC-27674 |
TS-002266
TUT4/7 inhibitor
|
TS-002266 is a potent and selective RNA terminal uridylyl transferase enzymes 4 and 7 (TUT4/7) inhibitor, blocks miRNA uridylation in vitro with biochemical IC50 of 69 and 16 nM for TUT4 and TUT7, respectively. |
| PC-27672 |
FUT8-IN-1
FUT8 inhibitor
|
FUT8-IN-1 is a potent, selective α-1,6-fucosyltransferase (FUT8) inhibitor with KD of 49 nM and IC50 50 uM. |
| PC-27658 |
ADAR1 inhibitor H13
ADAR1 inhibitor
|
ADAR1 inhibitor H13 is potent, orally bioavailable ADAR1 modulator, exhibits potent antiproliferative activity against various cancer cell lines and selectively reduces ADAR1-mediated editing of APOBEC3D in a dose-dependent manner. |
| PC-27639 |
KPSH02
RioK1 inhibitor
|
KPSH02 is a high affinity small molecule inhibitor of Rio Kinase 1 (RioK1) homolog from Archaeoglobus fulgidus (afRioK1) with SPR KD of 39.6 nM. |
| PC-27632 |
TTBK1 inhibitor 62
TTBK1 inhibitor
|
TTBK1 inhibitor 62 is a potent, selective, brain-penetrant ATP-competitive Tau tubulin kinase 1 (TTBK1) inhibitor with IC50 of 0.89 uM, >100-fold selective over TTBK2. |
