| Cat. No. |
Product Name |
Information |
| PC-27105 |
A2ti-1
S100A10-ANXA2 inhibitor
|
A2ti-1 (S100A10-ANXA2 heterotetramer inhibitor-1) is a specific small molecule Annexin A2 (ANXA2) inhibitor, inhibits Annexin A2-S100A10 protein interaction with IC50 of 24 uM (Annexin A2/S100A10 heterotetramer (A2t)). |
| PC-27102 |
TRMT10C agonist TM3
TRMT10C agonist
|
TRMT10C agonist TM3 is a small molecule agonist of tRNA methyltransferase 10C (TRMT10C), exhibits direct binding with a dissociation constant (Kd) of 2.6 uM in SPR assays, promotes osteoblast differentiation and protects against osteoporosis. |
| PC-27087 |
S428-1145
PUS7 inhibitor
|
S428-1145 is a small molecule inhibitor targeting pseudouridine synthase 7 (PUS7), has anti-proliferative IC50 of 20 µM in MIA PaCa-2 cells and 20.68 µM in PANC-1 cells, respectively, significantly inhibits tumour growth. |
| PC-27047 |
SKF-95667
GPR132 agonist
|
SKF-95667 is a potent, selective agonist of G-protein-coupled receptor GPR132 (G2A) with pEC50 of 6.6 and 5.8 in yeast and β-arrestin assays (human GPR132a). |
| PC-27046 |
GSK1820795A
GPR132 antagonist
|
GSK1820795A is a potent, specific antagonist of G-protein-coupled receptor GPR132 (G2A), blocks agonist-induced association of hGPR132 with β-arrestin with pIC50 of 7.8, also is a dual angiotensin AT1 antagonist and PPARγ modulator. |
| PC-26872 |
CPN-219
NMUR2 agonist
|
CPN-219 is a potent, selective, next-generation hexapeptidic neuromedin U receptor type 2 (NMUR2) agonist with EC50 value of 2.2 nM. |
| PC-26793 |
MDC134
Insulinotropic molecule
|
MDC134 is a glucose-dependent insulinotropic small molecule that enhances β-cell insulin secretion in pancreatic β-cells through Ca2+ influx and cAMP-associated amplification. |
| PC-26769 |
MEDS700
DHODH inhibitor
|
MEDS700 is a potent, selective, blood-brain barrier permeable hDHODH inhibitor with IC50 of 1.5 nM. |
| PC-26717 |
HF-125
TRIB2 inhibitor
|
HF-125 is a potent, selective small molecule inhibitor of Tribbles 2 (TRIB2), directly binds to destabilize and degrade TRIB2 proteins involving proteasomes and is effective both in vitro and in vivo. |
| PC-26684 |
LMT328
Sulfiredoxin inhibitor
|
LMT328 (LMT-328) is a potent inhibitor of sulfiredoxin (Srx) with IC50 of 6.7 uM. |
| PC-26615 |
ERG245
BCAT1 inhibitor
|
ERG245 is a potent, selective BCAT1 inhibitor with IC50 of 0.5 nM for recombinant human BCAT1 (rhBCAT1), >2000-fold selectivity for BCAT1 over BCAT2. |
| PC-26553 |
ZNF281 inhibitor ZIM
ZNF281 inhibitor
|
ZNF281 inhibitor ZIM (ZNF281 Interfering Molecule) is a specific small molecule inhibitor of transcription factor ZNF281, prevents anthracycline-mediated cardiotoxicity (AIC), enhances lung tumor regression, and prevents lung metastasis in a metastatic melanoma model. |
