| Cat. No. |
Product Name |
Information |
| PC-23517 |
ATX968
DHX9 inhibitor
|
ATX968 is a potent and selective inhibitor of DHX9 helicase activity with DHX9 unwinding IC50 of 8 nM, SPR Kd value of 1.3 nM. |
| PC-23494 |
Ibetazol
Importin β inhibitor
|
Ibetazol is novel specific small molecule inhibitor of importin β1 (KPNB1)-mediated nuclear import with EC50 of 6.3 uM in phenotypic importin α1 translocation assays , binds to cysteine 585 of importin β1. |
| PC-23304 |
PGMI-004A
PGAM1 inhibitor
|
PGMI-004A is a specific small molecule inhibitor of glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) with IC50 of 13.1 uM, Ki of 3.91 uM. |
| PC-23229 |
SLCB050
DX2-p14/ARF inhibitor
|
SLCB050 is a specific small molecule inhibitor of AIMP2-DX2-p14/ARF Interaction, inhibits lung cancer progression. |
| PC-23228 |
AM-001
EPAC1 inhibitor
|
AM-001 is a potent, selective and allosteric inhibitor of exchange proteins directly activated by cAMP 1 (EPAC1), inhibits Sp-8-CPT-induced Epac1 (EC50=47.8 uM) but not Epac2 activity. |
| PC-23227 |
Tirasemtiv
Fast skeletal troponin activator
|
Tirasemtiv (CK-2017357) is the first activator of fast skeletal muscle troponin with AC40 of 0.1 uM in in myofibril ATPase activity assays, shows potential for the treatment of amyotrophic lateral sclerosis. |
| PC-22641 |
TAK-448
KISS1R agonist
|
TAK-448 (MVT-602) is a potent and full KISS1R (metastin receptor) agonist and kisspeptin analogue with IC50 of 3 pM in radioimmunoassay. |
| PC-22534 |
TSLP inhibitor BP79
TSLP inhibitor
|
TSLP inhibitor BP79 is a specific small molecule inhibitor of thymic stromal lymphopoietin (TSLP), disrupts TSLP-TSLP receptor interaction and effectively abrogates TSLP-triggered cytokines at low micromolar concentrations. |
| PC-22494 |
CCG-1423
MKL1 inhibitor
|
CCG-1423 (CCG1423) is a small-molecule inhibitor of RhoA transcriptional signaling and serum response factor (SRF), blocks transcription activated by MKL1, disrupts transcriptional responses of the Rho pathway in cancer. |
| PC-22383 |
CDD-2807
STK33 inhibitor
|
CDD-2807 is a highly potent, selective inhibitor of serine/threonine kinase 33 (STK33) with biochemically Kd of 0.02 nM, IC50 of 9.2 nM in NanoBRET assays, induces contraceptive effect. |
| PC-22337 |
STL001
FOXM1 inhibitor
|
STL001 is a small molecule inhibitor of forkhead box protein M1 (FOXM1), suppresses FOXM1 protein levels in a variety of solid tumor-derived cancer cell lines. |
| PC-22243 |
FeM-1269
Ion mobilizer
|
FeM-1269 is a small molecule ion mobilizer, minimally aggregates and dose-dependently mobilizes iron across lipid bilayers, increases serum iron, transferrin saturation, hemoglobin and hematocrit in mouse model of anemia of inflammation. |
