| Cat. No. |
Product Name |
Information |
| PC-28707 |
CINS-1
RIOK1 inhibitor
|
CINS-1 is a potent, specific RIO Kinase 1 (RIOK1) inhibitor with high binding affinity (ITC Kd=97 nM, AfRIOK1), binds to human RIOK1 with a Kd of 176 nM, exhibits antiproliferative activity against CRC cell lines HCT116 with IC50 of 7.81 uM. |
| PC-28702 |
CDD-3094
STK33 inhibitor
|
CDD-3094 is a potent, selective Serine/threonine kinase 33 (STK33) inhibitor with IC50 of 56.3 nM and Kd of 0.087 nM, 21-fold selective over CLK4 (based on Kd value). |
| PC-28696 |
CH-126
ATF4/CHOP inhibitor
|
CH-126 is a specific small molecule inhibitor of CHOP/ATF4 (activating transcription factor 4/ C/EBP homologous protein) expression, inhibits ER stress-induced CHOP expression with IC50 of 2 uM in Tm&Tg induced-CHOP-Luc cells. |
| PC-28604 |
Z247611722
Serine palmitoyltransferase inhibitor, Antifungal
|
Z247611722 is a novel antifungal, inhibitor of sphingolipid biosynthesis and serine palmitoyltransferase (SPT), displays fungicidal activity against multiple Candida species (C. albicans, MIC=1.56 uM) and fluconazole-resistant isolates. |
| PC-28566 |
D-e-MAPP
Ceramidase inhibitor
|
D-e-MAPP (D-erythro-MAPP) is a ceramide analogue and specific inhibitor of alkaline ceramidase, inhibits alkaline ceramidase activity in vitro with IC50 of 1-5 uM. |
| PC-28550 |
Milategrast
Cell adhesion inhibitor
|
Milategrast (E6007) is a small molecule cell adhesion and cell infiltration inhibitor, inhibits the adhesion of Jurkat cells to human fibronectin with IC50 of <5 uM. |
| PC-28548 |
GR148672X
CES1 inhibitor
|
GR148672X (GR-148672X) is a specific small molecule inhibitor of Carboxylesterase 1 (CES1)/Triacylglycerol hydrolase (TGH), significantly increases glucose limitation (GL)-induced cell death in human CRC cell linees, counters CRC tumorigenesis in vivo. |
| PC-28510 |
Orniplabin
Plasminogen modulator, sEh inhibitor
|
Orniplabin (SMTP-7, Lemuplamor, Stachybotrys microspora triprenylphenol-7) is a fungal triprenyl phenol metabolite and plasminogen modulator, shows thrombolytic and anti-inflammatory effects, inhibits soluble epoxide hydrolase (sEH) to suppress inflammation, inhibits Cterm-EH and the Nterm-phos of sEH with IC50 of 23 uM and 6 uM. |
| PC-28496 |
DHPAAS inhibitor 1
Insect DHPAAS inhibitor
|
2,5,2',4'-tetrahydroxychalcone is a insect-specific inhibitor of DHPAAS 3,4-dihydroxyphenylacetaldehyde (DHPAA) synthase (DHPAAS), shows insecticide effect. |
| PC-28491 |
AKR-XI-85
RBP4 antatgonist
|
AKR-XI-85 is a potent, non-retinoid triazolopyrimidine Retinol-Binding Protein 4 (RBP4) antagonist with binding IC50 of 23 nM in SPA assay and 194 nM in TTR-RBP4 HTRF assay. |
| PC-28460 |
KPB82
ACER2 inhibitor
|
KPB82 is a potent and selective, competitive Alkaline ceramidase 2 (ACER2) inhibitor with IC50 of 190 nM, displaying minimal activity against ACER1, ACER3, ASAH1, or ASAH2. |
| PC-28457 |
ALCAT1-IN-1
ALCAT1 inhibitor
|
ALCAT1-IN-1 (Compound 222) is a potent and highly specific acyl-coenzyme A:lysocardiolipin acyltransferase-1 (ALCAT1) inhibitor with IC50 of <15 nM. |
