S428-1145

Chemical Structure : S428-1145

Catalog No.: PC-27087Not For Human Use, Lab Use Only.

S428-1145 is a small molecule inhibitor targeting pseudouridine synthase 7 (PUS7), has anti-proliferative IC50 of 20 µM in MIA PaCa-2 cells and 20.68 µM in PANC-1 cells, respectively, significantly inhibits tumour growth.

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Biological Activity

S428-1145 is a small molecule inhibitor targeting pseudouridine synthase 7 (PUS7), has anti-proliferative IC50 of 20 µM in MIA PaCa-2 cells and 20.68 µM in PANC-1 cells, respectively, significantly inhibits tumour growth.

Physicochemical Properties

M.Wt	451.53
Formula	C24H29N5O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]-1-{3-[3-(oxan-4-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}propan-1-one

References

1. Jike Fang, et al. Clin Transl Med. 2026 Jan;16(1):e70581.

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S428-1145

Biological Activity

Physicochemical Properties

References

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