Chemical Structure : SGM-3
CAS No.:
901584-62-1
SGM-3
(Striga germination modulator-3)
Catalog No.: PC-27202Not For Human Use, Lab Use Only.
Striga germination modulator-3 (SGM-3) is a potent, selective germination inhibitor for Striga hermonthica, selectively binds to ShHTL7 and shows inhibitory activity against YLG hydrolysis by ShHTL7 with IC50 of 2.3 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Striga germination modulator-3 (SGM-3) is a potent, selective germination inhibitor for Striga hermonthica, selectively binds to ShHTL7 and shows inhibitory activity against YLG hydrolysis by ShHTL7 with IC50 of 2.3 uM.
SGM-3 is a ShHTL7-selective competitive inhibitor, weakly inhibits ShHTL2 (IC50=14.6 uM) and has no activities for other ShHTLs (IC50>50 uM).
SGM-3 inhibits the Striga germination induced by SPL7 that selectively binds to ShHTL7.
SGM-3 also suppresses Striga germination even when induced by GR24 that can be perceived by multiple ShHTLs.
Physicochemical Properties
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M.Wt
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391.45
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Formula
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C17H24F3N3O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2,3,5-trifluoro-6-(piperidin-1-yl)-4-((2-(piperidin-1-yl)ethyl)sulfonyl)pyridine
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References
1. Michio Kuruma, et al. Precis Chem. 2026 Feb 13;4(6):768-773.
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