| Cat. No. |
Product Name |
Information |
| PC-25903 |
2-Bromopalmitate
Palmitoylation inhibitor
|
2-Bromopalmitate (2-Bromohexadecanoic acid, 2-Bromopalmitic acid) is a broad-spectrum palmitoylation inhibitor, inhibits ZDHHC11-mediated palmitoylation, inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis. |
| PC-25886 |
Them1 inhibitor Compound U11
Them1 inhibitor
|
Them1 inhibitor Compound U11 is a small molecule inhibitor of thioesterase superfamily member 1 (Them1) with IC50 of 3.63 uM, selectively inhibits Them1 by binding the START domain (Kd=0.67 uM). |
| PC-25885 |
Them1 inhibitor Compound U1
Them1 inhibitor
|
Them1 inhibitor Compound U1 is a small molecule inhibitor of thioesterase superfamily member 1 (Them1) with IC50 of 8.64 uM, selectively inhibits Them1 by binding the START domain (Kd=5.97 uM). |
| PC-25882 |
PPTD free base
ZIP14 inhibitor
|
PPTD free base is the first selective small-molecule inhibitor of membrane-bound metal transporter ZIP14/SLC39A14, efficiently blocks ZIP14-mediated uptake of zinc, iron, manganese and cadmium, while sparing the closely related transporter ZIP8/SLC39A8. |
| PC-25881 |
ZIP14 inhibitor PPTD
ZIP14 inhibitor
|
ZIP14 inhibitor PPTD is the first selective small-molecule inhibitor of membrane-bound metal transporter ZIP14/SLC39A14, efficiently blocks ZIP14-mediated uptake of zinc, iron, manganese and cadmium, while sparing the closely related transporter ZIP8/SLC39A8. |
| PC-25857 |
PF-429242 dihydrochloride
S1P inhibitor
|
PF-429242 dihydrochloride (PF429242) is a potent, selective, reversible and competitive inhibitor of proprotein convertase SREBP site 1 protease (S1P, Subtilisin kexin isozyme-1/SKI-1, MBTPS1) with IC50 of 170 nM. |
| PC-25841 |
3-Nitrooxypropanol
MCR inhibitor
|
3-Nitrooxypropanol (Abrucomstat, 3-NOP) is a small molecule inhibitor of methane formation in the rumen, specifically inhibits methyl-coenzyme M reductase (MCR), inhibit methanogenesis, in vitro and in vivo. |
| PC-25820 |
TP-5801
TNK1 inhibitor
|
TP-5801 is a potent, specific inhibitor of Thirty-eight-negative kinase-1 (TNK1) with IC50 of 1.4 nM, inhibits TNK1-transformed cells. |
| PC-25819 |
AP232
U2AF1-UHM inhibitor
|
AP232 is a specific small molecule splicing factor U2AF-UHM inhibitor with IC50 of 7.96 uM, targets the U2 auxiliary homology motif (UHM) of U2AF1, displays 3-24-fold selectivity against other UHM proteins (RBM39-, SPF45-, PUF60-, and U2AF2-UHM). |
| PC-25818 |
DS89092425
PUF60-UHM inhibitor
|
DS89092425 is a small molecule RNA splicing factor PUF60-UHM inhibitor with ITC KD of 83 uM. |
| PC-25817 |
Claudin 5 binder CL5B
CLDN5 binder
|
Claudin 5 binder CL5B is a small molecule binder of Claudin 5 (CLDN5), binds directly to hCLDN5 with KD of 31.7 uM, opens the blood-brain barrier and safely enhances brain drug delivery. |
| PC-25798 |
YL0441
ΔFOSB inhibitor
|
YL0441 is a highly effective inhibitor of AP1 transcription factor ΔFOSB with IC50 of 13.7 uM and 12.3 uM, disrupts ΔFOSB/JUND and ΔFOSB/ΔFOSB binding to DNA, inhibits AP1-transcription factor-mediated expression of the luciferase reporter gene with IC50 of 0.1 uM. |
