FUT8 Inhibitor 40

Chemical Structure : FUT8 Inhibitor 40

Catalog No.: PC-23122Not For Human Use, Lab Use Only.

FUT8 Inhibitor 40 is a selective, cell-active inhibitor of α-1,6-fucosyltransferase (FUT8), inhibits FUT8 without inhibiting other FUTs.

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Biological Activity

FUT8 Inhibitor 40 is a selective, cell-active inhibitor of α-1,6-fucosyltransferase (FUT8), inhibits FUT8 without inhibiting other FUTs.
FUT8 Inhibitor 40 (20 uM) significantly inhibited FUT8 activity in a cell-based assay, suppressed phosphorylation of EGFR in HepG2 hepatoma cells.
FUT8 Inhibitor 40 suppresses T-cell inflammatory responses, indicating a potential use as an immunomodulator.

Physicochemical Properties

M.Wt	529.08
Formula	C32H33ClN2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((6-chloro-1-((4-ethyl-2-phenylpiperazin-1-yl)methyl)naphthalen-2-yl)oxy)methyl)phenyl acetate

References

1. Manabe Y, et al. Angew Chem Int Ed Engl. 2024 Sep 28:e202414682.

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