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FUT8 Inhibitor 40

Chemical Structure : FUT8 Inhibitor 40

CAS No.: 3073704-72-7

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FUT8 Inhibitor 40 (FUT8-IN-2)

Catalog No.: PC-23122Not For Human Use, Lab Use Only.

FUT8 Inhibitor 40 (FUT8-IN-2) is a selective, cell-active inhibitor of α-1,6-fucosyltransferase (FUT8), inhibits FUT8 without inhibiting other FUTs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    FUT8 Inhibitor 40 (FUT8-IN-2) is a selective, cell-active inhibitor of α-1,6-fucosyltransferase (FUT8), inhibits FUT8 without inhibiting other FUTs.
    FUT8 Inhibitor 40 (20 uM) significantly inhibited FUT8 activity in a cell-based assay, suppressed phosphorylation of EGFR in HepG2 hepatoma cells.
    FUT8 Inhibitor 40 suppresses T-cell inflammatory responses, indicating a potential use as an immunomodulator.

    Physicochemical Properties

    M.Wt 529.08
    Formula C32H33ClN2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(((6-chloro-1-((4-ethyl-2-phenylpiperazin-1-yl)methyl)naphthalen-2-yl)oxy)methyl)phenyl acetate

    References

    1. Manabe Y, et al. Angew Chem Int Ed Engl. 2024 Sep 28:e202414682.

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