| Cat. No. |
Product Name |
Information |
| PC-27718 |
UM-1098
Mincle agonist, Vaccine adjuvant
|
UM-1098 is a synthetic macrophage-Inducible C-type Lectin (Mincle) agonist, induces Th17, Th1, Th2 polarizing innate cytokines in mouse PBMCs, induces strong Th1 and Th17 immunity after vaccination with Mtb antigens. |
| PC-27691 |
GO1323
HsCRY1 modulator
|
GO1323 is a photopharmacological light-switchable modulator of human clock protein cryptochrome-1 (HsCRY1), selectively binds to HsCRY1, enables light-controlled manipulation of the circadian rhythm via photoisomerization. |
| PC-27642 |
DHX8-IN-1
DHX8 inhibitor
|
DHX8-IN-1 (Compound 53) is a potent, specific inhibitor of spliceosomal DEAH-box RNA helicase DHX8, inhibits DHX9 ATP-hydrolysis with IC50 of 43 nM in biochemical ADP-Glo assays, and 120 nM in RNA FA (fluorescence anisotropy) binding assays. |
| PC-27635 |
MAT2A inhibitor ZS97
MAT2A inhibitor
|
MAT2A inhibitor ZS97 is a potent, selective and orally bioavailable methionine adenosyltransferase 2A (MAT2A) inhibitor, demonstrates potent enzymatic inhibition, effectively depleting intracellular SAM and suppressing downstream PRMT5-mediated methylation. |
| PC-27631 |
17β-HSD13-IN-1
17β-HSD13 inhibitor
|
17β-HSD13-IN-1 is a potent, selective hydroxysteroid 17-β-dehydrogenase 13 (17β-HSD13) inhibitor with cell IC50 of 14 nM, has >3000-fold seletivity over 17β-HSD1. |
| PC-27624 |
Transketolase-IN-1
Transketolase inhibitor
|
Transketolase-IN-1 (Compound 5aw) is a small molecule Transketolase (TK, EC 2.2.1.1) inhibitor, tightly binds with the enzyme At TK, exhibits potent postemergence herbicidal activity. |
| PC-27619 |
Latrunculin B
Actin polymerization inhibitor
|
Latrunculin B is an antimicrobial marine alkaloid and actin polymerization inhibitor, disrupts microfilament organization and affects cell growth, sequesters monomeric G-actin, leading to the disassembly of actin filaments in cells. |
| PC-27618 |
Latrunculin A
Actin polymerization inhibitor
|
Latrunculin A (LAT-A) is a natural compound isolated from red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor, binds to actin monomers and inhibits polymerization of actin with Kd of 0.1, 0.4, 4.7 and 0.19 uM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. |
| PC-27609 |
N-arachidonylglycine
GPR18 agonist, GPR92 agonist
|
N-Arachidonylglycine (NAGly, NA-Gly) is a carboxylic analog of the endocannabinoid anandamide (AEA) and endogenous ligand/agonist of GPR18 with EC50 of 44.5 nM, also is a endogenous agaonist of orphan G protein-coupled receptor GPR92 with EC50 of 4.47 uM. |
| PC-27608 |
Protoporphyrin IX disodium
CAS 50865-01-5
|
Protoporphyrin IX disodium (Proto IX, PPIX) is the branch point in chloroplast tetrapyrrole biosynthesis, also acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage, also is a dye content for fluorescence spectroscopic assays. |
| PC-27607 |
Protoporphyrin IX
CAS 553-12-8
|
Protoporphyrin IX (Proto IX, PPIX) is the branch point in chloroplast tetrapyrrole biosynthesis, also acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage, also is a dye content for fluorescence spectroscopic assays. |
| PC-27606 |
N-methyl protoporphyrin IX
FECH inhibitor
|
N-methyl protoporphyrin IX (NMPP, N-MPP) is a selective Ferrochelatase (FECH) antagonist with Ki app pf 3 nM, inhibits heme synthesis, also inhibits nitric oxide synthase isoforms nNOS, iNOS, and eNOS with IC50 of 5-8 uM. |
