Neocarzilin A | VAT1 inhibitor | Probechem Biochemicals

Chemical Structure : Neocarzilin A

Neocarzilin A (NCA)

Catalog No.: PC-23697Not For Human Use, Lab Use Only.

Neocarzilin A (NCA) is a potent inhibitor of cancer cell migration, irreversibly binds to and inhibits the synaptic vesicle membrane protein VAT-1.

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Biological Activity

Neocarzilin A (NCA) is a potent inhibitor of cancer cell migration, irreversibly binds to and inhibits the synaptic vesicle membrane protein VAT-1.
Neocarzilin A (NCA) shows potent cytotoxicity against K562 chronic myelogenous leukemia cells with IC50 of 185 nM.
Neocarzilin A (NCA) reduces angiosarcoma migration.

Physicochemical Properties

M.Wt	323.64
Formula	C14H17Cl3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,3Z,5E,7E,9E)-1,1,1-trichloro-4-hydroxy-11-methyltrideca-3,5,7,9-tetraen-2-one

References

1. Gleissner CM, et al. ACS Cent Sci. 2019 Jul 24;5(7):1170-1178.

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Neocarzilin A (NCA)

Biological Activity

Physicochemical Properties

References

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