Catalog No.: PC-23556Not For Human Use, Lab Use Only.
Purpurin is a potent, specific inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1) with Ki of 1.9 uM, inhibits cancer cell proliferation and tumor growth.
Purpurin is a potent, specific inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1) with Ki of 1.9 uM, inhibits cancer cell proliferation and tumor growth. Purpurin specifically inhibits activity of GDH but not other NADPH-dependent enzymes such as 6-phosphogluconate dehydrogenase (6PGD) and fumarate hydratase (FH) in vitro. Purpurin exerts dose-dependently antidepressant-like effects on behavior and stress axis reactivity in adult male C57BL/6J mice.
Physicochemical Properties
M.Wt
256.21
Formula
C14H8O5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,2,4-Trihydroxyanthracene-9,10-dione
References
1. Jin L, et al. Cancer Cell. 2015 Feb 9;27(2):257-70.
2. Ma L, et al. Psychopharmacology (Berl). 2020 Mar;237(3):887-899.
