| Cat. No. |
Product Name |
Information |
| PC-24039 |
RUN-47
NRF1 activator
|
RUN-47 is a small-molecule activator of NRF1 with EC50 of 6.43 uM in 3xPSMA4-ARE-LUC reporter assays, specifically activates NRF1 pathway. |
| PC-24030 |
Diacerein
IL-1β inhibitor
|
Diacerein (Diacerhein) is an orally active anthraquinone, reduces production of IL-1 converting enzyme then inhibits the activation of IL-1β by related downstream signaling, also is a highly efficacious inhibitor of main protease (Mpro) of SARS-CoV-2, shows anti-inflammatory and anti-rheumatic effect. |
| PC-24009 |
Apigenin
MARK4 inhibitor
|
Apigenin is a small molecule inhibitor of Microtubule Affinity-Regulating Kinase 4 (MARK4) with IC50 of 2.39 uM, exerts neuroprotective effects. |
| PC-24008 |
ST-5-002
TM4SF5 inhibitor
|
ST-5-002 is a specific small molecule inhibitor of transmembrane 4 L six family member 5 (TM4SF5), inhibits signaling lymphocytic activation molecule family member 7 (SLAMF7) degradation due to TM4SF5 binding and lysosomal translocation. |
| PC-24006 |
Dracorhodin
CMPK2 inhibitor
|
Dracorhodin is the main component in sanguis draconis that can induce vasodilatation, inhibits cytidine/uridine monophosphate kinase 2 (CMPK2) and attenuates inflammation. |
| PC-23998 |
GJG057
LTC4S inhibitor
|
GJG057 is a potent, selective and orally bioavailable inhibitor of leukotriene C4 synthase (LTC4S) with IC50 of 44 nM in whole blood LTC4 release assay and 14 nM in enzymatic assays. |
| PC-23996 |
ZYS-1
ADAR1 inhibitor
|
ZYS-1 is a potent small-molecule ADAR1 (denosine deaminase acting on RNA 1) inhibitor, suppresses PCa growth and metastasis and potentiated the antitumor immune response. |
| PC-23983 |
AM-3607
GlyR PAM
|
AM-3607 is a potent, positive allosteric modulator of mammalian ionotropic glycine receptor (GlyR) subtypes with EC50 of 25 nM (hGlyRα3β), SPR Kd of 11 nM. |
| PC-23982 |
AM-1488
GlyR PAM
|
AM-1488 is a potent, positive allosteric modulator of mammalian ionotropic glycine receptor (GlyR) subtypes with EC50 of 0.45 uM (hGlyRα3β), SPR Kd of 0.19 uM. |
| PC-23969 |
BPK-21
ERCC3 inhibitor
|
BPK-21 is a specific inhibitor of helicase ERCC3, suppresses T cell activation through blockade of ERCC3 function, targets C342 in ERCC3. |
| PC-23968 |
BPK-25
NuRD inhibitor
|
BPK-25 is a small molecule inhibitor of Nucleosome Remodeling and Deacetylation Complex (NuRD), suppresses T-cell activation at low-μM concentrations without causing cytotoxicity. |
| PC-23950 |
PKRA7
PK2 antagonist
|
PKRA7 (PKRA83) is a potent polypeptide chemokine PK2 (Bv8, PROK2) antagonist, potently inhibit PK2 receptors with IC50 of 5.0 and 8.2 nM for PKR1 and PKR2, respectively. |
