| Cat. No. |
Product Name |
Information |
| PC-21942 |
PU.1 inhibitor A11
PU.1 inhibitor
|
PU.1 inhibitor A11 is a small molecule inhibitor of transcription factor PU.1 with EC50 of 2.5 nM in reporter assays, moderates the inflammatory response in human iPSC-derived microglia-like cells (iMGLs) by downregulating inflammatory PU.1-target gene expression without affecting hematopoiesis. |
| PC-21926 |
AZ9567
MAT2A inhibitor
|
AZ9567 is a potent, selective methionine adenosyltransferase 2A (MAT2A) inhibitor with IC50 of 1 nM, selectively targets MTAP-deficient cancer cells. |
| PC-21924 |
MAGMAS inhibitor BT9
MAGMAS inhibitor
|
MAGMAS inhibitor BT9 is a small molecule MAGMAS (mitochondria associated, granulocyte-macrophage colony stimulating factor signaling molecule) inhibitor with binding Kd of 33 uM. |
| PC-21923 |
Epoxykynin
sEH inhibitor
|
Epoxykynin is a potent, selective soluble epoxide hydrolase (sEH) with IC50 of 36 nM, inhibits the hydrolase activity of sEH and modulates kynurenine pathway. |
| PC-21895 |
MAT2A inhibitor 29
MAT2A inhibitor
|
MAT2A inhibitor 29 (AZ-29) is a potent and selective inhibitor of methionine adenosyltransferase MAT2A with IC50 of 27.9 nM. |
| PC-21894 |
IDE-397
MAT2A inhibitor
|
IDE-397 (GSK-4362676, GSK-676) is a potent, selective small molecule methionine adenosyltransferase 2a (MAT2A) inhibitor, displays broad anti-tumor activity across a panel of MTAP-deleted patient-derived xenografts. |
| PC-21877 |
AKST1220
LTA4H inhibitor
|
AKST1220 is a potent, specific leukotriene A4 hydrolase (LTA4H) inhibitor, improves hippocampal dependent memory. |
| PC-21876 |
MIF agonist MIF20
MIF agonist
|
MIF agonist MIF20 is an allosteric small molecule agonist of macrophage migration inhibitory factor (MIF), binds to MIF and increases its affinity for the cognate MIF receptor CD74, increasing the strength of downstream signal transduction. |
| PC-21871 |
FEN1-IN-4
FEN1 inhibitor
|
FEN1-IN-4 is a specific, competitive inhibitor of human flap endonuclease-1 (hFEN1) with IC50 of 30 nM, binds to atalytic metals and blocks DNA unpairing. |
| PC-21866 |
Them1 inhibitor U1
Them1 inhibitor
|
Them1 inhibitor U1 is a selective, allosteric small molecule inhibitor of thioesterase superfamily member 1 (Them1) with IC50 of 8.64 uM, selectively bind the Them1 START domain with Kd of 5.97 uM. |
| PC-21865 |
PCiB-3
Phosphatidylcholine synthesis inhibitor
|
PCiB-3 is a small molecule inhibitor capable of inhibiting phosphatidylcholine (PC) biogenesis with IC50 of 0.4 uM, inhibits the phosphatidylethanolamine (PE) methyltransferase activity of Cho2. |
| PC-21864 |
PCiB-2
Phosphatidylcholine synthesis inhibitor
|
PCiB-2 is a small molecule inhibitor capable of inhibiting phosphatidylcholine (PC) biogenesis with IC50 of 2.0 uM, inhibits the phosphatidylethanolamine (PE) methyltransferase activity of Cho2, induces mitochondrial division. |
