Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-CD73 inhibitor XC-12
CD73 inhibitor XC-12

Chemical Structure : CD73 inhibitor XC-12

CAS No.:

Add to Favorites

CD73 inhibitor XC-12

Catalog No.: PC-24682Not For Human Use, Lab Use Only.

CD73 inhibitor XC-12 is a potent, orally bioactive CD73 inhibitor with IC50 of 12.36 and 1.29 nM against both soluble and membrane-bound forms (hCD73).

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CD73 inhibitor XC-12 is a potent, orally bioactive CD73 inhibitor with IC50 of 12.36 and 1.29 nM against both soluble and membrane-bound forms (hCD73).
XC-12 exhibits potent antiproliferative activity. orally bioavailable and significantly inhibited the tumor growth in the CT26 syngeneic mouse model (TGI: 74%) at a dose of 135 mg/kg.

Physicochemical Properties

M.Wt 460.37
Formula C20H15F3N6O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-4-((1-(6-(2,4-Dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3-oxo-2,3-dihydropyridazin-4-yl)pyrrolidin-3-yl)oxy)-2-(trifluoromethyl)benzonitrile

References

1. Lifang Cen, et al. J Med Chem. 2025 May 23. doi: 10.1021/acs.jmedchem.5c00035.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: