| Cat. No. |
Product Name |
Information |
| PC-63448 |
LBL1
Lamin A inhibitor
|
LBL1 (Lamin A inhibitor LBL1) is a novel pyrroloquinazoline compound with significant anticancer activity, targets nuclear lamins and binds to the coiled-coil domain of lamin A (Kd=5.11 uM). |
| PC-63447 |
Syn-TEF1
Tanscription modualtor
|
Syn-TEF1 is a molecule actively enables transcription across repressive GAA repeats that silence frataxin expression in Friedreich's ataxia, license transcription elongation at targeted genomic loci. |
| PC-63439 |
PH002
ApoE4 inhibitor
|
PH002 is a small-molecule structure corrector significantly decreased ApoE4 fragment levels in ApoE4/4-hiPSC-derived neurons, increases GABAergic neuron numbers and GAD67 levels, reduces p-tau levels, and decreases Aβ40 and Aβ42 production and/or secretion. |
| PC-63409 |
JNJ-26993135
LTA4H inhibitor
|
JNJ-26993135 is a potent, selective leukotriene A4 hydrolase (LTA4H) inhibitor, inhibits both the epoxide hydrolase and aminopeptidase activities of recombinant human LTA4H with IC50 of 10 nM. |
| PC-63371 |
Oxythiamine chloride hydrochloride
Transketolase inhibitor
|
Oxythiamine chloride is a small molecule transketolase inhibitor with Kd of 33 nM, shows functional assay of human transketolase inhibition in HCT-116 cells with EC50 of 26 nM. |
| PC-63363 |
TMP-153
ACAT inhibitor
|
TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals. |
| PC-63355 |
Compound-326
D5D/FADS1 inhibitor
|
Compound-326 (D5D inhibitor 326, D5D-IN-326) is apotent, selective, orally active delta-5 desaturase (D5D, FADS1/Fatty Acid Desaturase 1) with IC50 of 72 and 22 nM for rat and human D5D, respectively. |
| PC-63354 |
T-3861174
prolyl tRNA synthetase inhibitor
|
T-3861174 is a small molecule prolyl tRNA synthetase (PRS) inhibitor with binding IC50 of 2.3 nM. |
| PC-63336 |
AZ-1355
|
AZ-1355 is an effctive lipid-lowering compound that inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro.. |
| PC-63313 |
IP6K1 inhibitor TNP
IP6K inhibitor
|
IP6K1 inhibitor TNP is a potent, selective inositol hexakisphosphate kinase IP6K with IC50 of 0.47 uM (IP6K1), does not inhibit either human or yeast Vip/PPIP5K. |
| PC-63307 |
TLSC702
hGLO I inhibitor
|
TLSC702 is a novel potent inhibitor of human glyoxalase I (hGLO I) with IC50 of 2.0 uM. |
| PC-63266 |
ABL127
PME-1 inhibitor
|
ABL127 (ML174) is a potent, selective, covalent inhibitor of protein methylesterase 1 (PME-1) with IC50 of 10 nM. |
