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FTBMT

Chemical Structure : FTBMT

CAS No.: 1358575-02-6

FTBMT (TP024, TP-024)

Catalog No.: PC-35386Not For Human Use, Lab Use Only.

FTBMT (TP024) is a novel selective GPR52 agonist, increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50 of 7.03, 6.85, and 6.87M, respectively.

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Biological Activity

FTBMT (TP024) is a novel selective GPR52 agonist, increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50 of 7.03, 6.85, and 6.87M, respectively.
FTBMT does not show significant inhibition or stimulation in a panel of 98 other targets, including receptors, ion channels, and enzymes.
FTBMT elevates the levels of cAMP (pEC50=6.82) and phosho-CREB, which increased the expression of downstream CREB target genes, c-fos and Egr-2.
FTBMT inhibits MK-801-induced hyperactivity, shows antipsychotic and recognitive properties without causing catalepsy in rodents.

Physicochemical Properties

M.Wt 392.35
Formula C19H16F4N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(3-(3-Fluoro-5-(trifluoromethyl)benzyl)-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide

References

1. Nishiyama K, et al. J Pharmacol Exp Ther. 2017 Nov;363(2):253-264.

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