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Chemical Structure : FTBMT
CAS No.: 1358575-02-6
Catalog No.: PC-35386Not For Human Use, Lab Use Only.
FTBMT (TP024) is a novel selective GPR52 agonist, increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50 of 7.03, 6.85, and 6.87M, respectively.
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|---|---|---|---|
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| 10 mg | $138 | In stock | |
| 25 mg | $238 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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FTBMT (TP024) is a novel selective GPR52 agonist, increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50 of 7.03, 6.85, and 6.87M, respectively.
FTBMT does not show significant inhibition or stimulation in a panel of 98 other targets, including receptors, ion channels, and enzymes.
FTBMT elevates the levels of cAMP (pEC50=6.82) and phosho-CREB, which increased the expression of downstream CREB target genes, c-fos and Egr-2.
FTBMT inhibits MK-801-induced hyperactivity, shows antipsychotic and recognitive properties without causing catalepsy in rodents.
| M.Wt | 392.35 | |
| Formula | C19H16F4N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(3-(3-Fluoro-5-(trifluoromethyl)benzyl)-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide |
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1. Nishiyama K, et al. J Pharmacol Exp Ther. 2017 Nov;363(2):253-264.
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