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Desmethyl dabrafenib

Chemical Structure : Desmethyl dabrafenib

CAS No.: 1195765-47-9

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Desmethyl dabrafenib (GSK2167542, Dabrafenib metabolite M8)

Catalog No.: PC-35415Not For Human Use, Lab Use Only.

Desmethyl dabrafenib (GSK2167542, Dabrafenib metabolite M8) is the desmethyl- metabolic byproduct of Dabrafenib, ameliorates developmental pathologies of Kabuki Syndrome in vivo..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Desmethyl dabrafenib (GSK2167542, Dabrafenib metabolite M8) is the desmethyl- metabolic byproduct of Dabrafenib, ameliorates developmental pathologies of Kabuki Syndrome in vivo.

    Physicochemical Properties

    M.Wt 505.534
    Formula C22H18F3N5O2S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[3-[5-(2-aminopyrimidin-4-yl)-2-propan-2-yl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide

    References

    1. Bershas DA, et al. Drug Metab Dispos. 2013 Dec;41(12):2215-24.

    2. Ouellet D, et al. J Clin Pharmacol. 2014 Jun;54(6):696-706.

    3. Suttle AB, et al. J Clin Pharmacol. 2015 Apr;55(4):392-400.

    4. Tsai IC, et al. Sci Rep. 2018 Jul 17;8(1):10779.

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