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Chemical Structure : Edonerpic maleate
CAS No.: 519187-97-4
Catalog No.: PC-35371Not For Human Use, Lab Use Only.
Edonerpic maleate (T-817MA) is a neurotrophic agent that can protects neuronal cells and modifies their morphology, binds to collapsin-response-mediator-protein 2 (CRMP2) and inhibits amyloid-β peptides (Aβ).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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Edonerpic maleate (T-817MA) is a neurotrophic agent that can protects neuronal cells and modifies their morphology, binds to collapsin-response-mediator-protein 2 (CRMP2) and inhibits amyloid-β peptides (Aβ).
Edonerpic maleate binds to collapsin-response-mediator-protein 2 (CRMP2) with Kd of 7.35 x 10−4 M.
Edonerpic maleate attenuates amyloid-beta-induced neurotoxicity and promotes neurite outgrowth in rat cultured central nervous system neurons.
Edonerpic maleate ameliorates the deficits in adult neurogenesis and spatial memory in rats infused i.c.v. with amyloid-beta peptide.
| M.Wt | 407.481 | |
| Formula | C20H25NO6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}azetidin-3-ol maleate |
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1. Abe H, et al. Science. 2018 Apr 6;360(6384):50-57.
2. Hirata K, et al. J Pharmacol Exp Ther. 2005 Jul;314(1):252-9.
3. Fukushima T, et al. Biochem Biophys Res Commun. 2011 Apr 22;407(4):730-4.
4. Kimura T, et al. Br J Pharmacol. 2009 Jun;157(3):451-63.
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