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Chemical Structure : GAK inhibitor 49
CAS No.: 319492-82-5
Catalog No.: PC-35412Not For Human Use, Lab Use Only.
GAK inhibitor 49 is a potent, selective, ATP-competitive inhibitor of cyclin G-associated kinase (GAK, cell IC50=56 nM) with favourable NAK family selectivity (AAK1, STK16, BMP2K).
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GAK inhibitor 49 is a potent, selective, ATP-competitive inhibitor of cyclin G-associated kinase (GAK, cell IC50=56 nM) with favourable NAK family selectivity (AAK1, STK16, BMP2K).
GAK inhibitor 49 shows binding to only GAK and RIPK2 in an unbiased MIB/MS experiment in cell lysate.
| M.Wt | 370.405 | |
| Formula | C20H22N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine |
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1. Asquith CRM, et al. ChemMedChem. 2018 Jan 8;13(1):48-66.
2. Pu SY, et al. J Med Chem. 2018 Jul 16. doi: 10.1021/acs.jmedchem.8b00613.
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