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GAK inhibitor 49

Chemical Structure : GAK inhibitor 49

CAS No.: 319492-82-5

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GAK inhibitor 49

Catalog No.: PC-35412Not For Human Use, Lab Use Only.

GAK inhibitor 49 is a potent, selective, ATP-competitive inhibitor of cyclin G-associated kinase (GAK, cell IC50=56 nM) with favourable NAK family selectivity (AAK1, STK16, BMP2K).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GAK inhibitor 49 is a potent, selective, ATP-competitive inhibitor of cyclin G-associated kinase (GAK, cell IC50=56 nM) with favourable NAK family selectivity (AAK1, STK16, BMP2K).
GAK inhibitor 49 shows binding to only GAK and RIPK2 in an unbiased MIB/MS experiment in cell lysate.

Physicochemical Properties

M.Wt 370.405
Formula C20H22N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine

References

1. Asquith CRM, et al. ChemMedChem. 2018 Jan 8;13(1):48-66.

2. Pu SY, et al. J Med Chem. 2018 Jul 16. doi: 10.1021/acs.jmedchem.8b00613.

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