IGS-1.76 | NCS-1/Ric8a inhibitor | Probechem Biochemicals

Chemical Structure : IGS-1.76

CAS No.: 313480-47-6

IGS-1.76 (IGS1.76)

Catalog No.: PC-35410Not For Human Use, Lab Use Only.

IGS-1.76 is a small molecule inhibitor of human NCS-1/Ric8a interaction with affinity of 1.25 uM (hNCS-1).

Packing	Price	Stock
5 mg	$158	In stock
10 mg	$238	In stock
25 mg	$398	In stock
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Biological Activity

IGS-1.76 is a small molecule inhibitor of human NCS-1/Ric8a interaction with affinity of 1.25 uM (hNCS-1).
IGS-1.76 demonstrates improved binding potency over the phenothiazine FD44, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model.

Physicochemical Properties

M.Wt	358.459
Formula	C22H18N2OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(benzo[d]thiazol-2-yl)-3,3-diphenylpropanamide

References

1. Roca C, et al. J Med Chem. 2018 Jul 17. doi: 10.1021/acs.jmedchem.8b00088.

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IGS-1.76 (IGS1.76)

Biological Activity

Physicochemical Properties

References

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