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IGS-1.76

Chemical Structure : IGS-1.76

CAS No.: 313480-47-6

IGS-1.76 (IGS1.76)

Catalog No.: PC-35410Not For Human Use, Lab Use Only.

IGS-1.76 is a small molecule inhibitor of human NCS-1/Ric8a interaction with affinity of 1.25 uM (hNCS-1).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

IGS-1.76 is a small molecule inhibitor of human NCS-1/Ric8a interaction with affinity of 1.25 uM (hNCS-1).
IGS-1.76 demonstrates improved binding potency over the phenothiazine FD44, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model.

Physicochemical Properties

M.Wt 358.459
Formula C22H18N2OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(benzo[d]thiazol-2-yl)-3,3-diphenylpropanamide

References

1. Roca C, et al. J Med Chem. 2018 Jul 17. doi: 10.1021/acs.jmedchem.8b00088.

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