| Cat. No. |
Product Name |
Information |
| PC-26468 |
NCGC00238624
GALK1 inhibitor
|
NCGC00238624 is a highly selective galactokinase (GALK1) inhibitor with IC50 of 7.69 and 13.67 uM against the human and mouse recombinant GALK1, respectively, lowers gal-1P levels in primary fibroblast cells derived from patients with classic galactosemia. |
| PC-26467 |
GALK1-IN-1
GALK1 inhibitor
|
GALK1-IN-1 is an effective ATP-competitive galactokinase 1 (GALK1) inhibitor with IC50 of 1 uM in luminescence GALK-ATP-depletion assay. |
| PC-26445 |
PON2 inhibitor 2
PON2 inhibitor
|
PON2 inhibitor 2 is a potent, specific small molecule inhibitor of paraxonase 2 (PON2) with IC50 of 56 nM, inhibits the lactonase activity of PON2. |
| PC-26444 |
TQ416
PON2 inhibitor
|
TQ416 is a small molecule paraoxonase 2 (PON2) inhibitor, restores NF-κB transcriptional activity suppressed by N-(3-oxododecanoyl)-L-homoserine lactone (3OC12HSL, C12) with IC50 of 400 nM, rescues 3OC12HSL-induced cell death. |
| PC-26427 |
PKR1 agonist IS39
PKR1 agonist
|
PKR1 agonist IS39 is a selective, metabolically stable, non-peptide Prokineticin receptor-1 (PKR1, PROKR1) agonist, protects cardiomyocytes from doxorubicin-induced cytotoxicity. |
| PC-26416 |
NFYi5
NF-Y inhibitor
|
NFYi5 is a specific small molecule inhibitor of Nuclear Transcription Factor-Y (NF-Y), inhibits NF-Y-dependent transcriptional activity, dose dependently inhibits activity of the NF-Y reporter in both human and rat cardiac fibroblasts with IC50 of 19.95 and 12.73 uM respectively. |
| PC-26389 |
CZ-48
SARM1 activator
|
CZ-48 (Sulfo-ara-F-NMN) is a mimetic of nicotinamide mononucleotide (NMN) and selective cell-permeant activator of SARM1, activate SARM1 to produce cADPR from NAD, does not inhibit CD38. |
| PC-26386 |
IVMT-Rx-4
MDA-9/Syntenin inhibitor
|
IVMT-Rx-4 is a small molecule inhibitor of MDA-9/Syntenin, specifically interrupt MDA-9/Syntenin signaling, leading to an inhibition in progression of PC cells to bone metastasis. |
| PC-26377 |
NBDHEX
GST inhibitor
|
NBDHEX is a potent glutathione S-transferase (GST) inhibitor, inhibits human glutathione S-transferases GSTA1-1, GSTP1-1 and GSTM2-2 with IC50 of 25 uM, 0.8 uM and <0.01 uM, is cytotoxic toward P-glycoprotein-overexpressing tumor cell lines. |
| PC-26371 |
OXGR1 agonist A-1
OXGR1 agonist
|
OXGR1 agonist A-1 is a potent and selective OXGR1 (Oxoglutarate Receptor 1, GPR99) agonist, activates Gq signaling of OXGR1 with EC50 of 626.5 nM. |
| PC-26353 |
Rexaceract
GCase PAM, GCase activator
|
Rexaceract (GT-02287) is a potent, selective positive allosteric modulator (PAM) of beta-glucocerebrosidase (β-glucocerebrosidase, β-glucosidase, or GCase) with KD of 17-24 uM at pH 7.4, enhances the function of lysosomal GCase. |
| PC-26317 |
VRK-IN-1
VRK1/VRK2 inhibitor
|
VRK-IN-1 is a potent, selective inhibitor of Vaccinia-related kinases 1 and 2 (VRK1 and VRK2) with ITC KD values of 190 nM and 401 nM, IC50 of 150 nM (VRK1). |
