| Cat. No. |
Product Name |
Information |
| PC-38755 |
CT-179
OLIG2 inhibitor
|
CT-179 is a small molecule inhibitor of protein transcription factor OLIG2 (Oligodendrocyte transcription factor 2), CT-179 is a putative disruptor of OLIG2 homodimerization. |
| PC-38753 |
PAT1inh-B01
SLC26A6 (PAT1) inhibitor
|
PAT1inh-B01 is a small-molecule, selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor, could fully inhibit PAT1-mediated anion exchange with IC50 of 350 nM. |
| PC-38736 |
DX3-213B
OXPHOS inhibitor
|
DX3-213B is a potent oxidative phosphorylation (OXPHOS) complex I inhibitor with IC50 of 3.6 nM, inhibits pancreatic cancer cells growth in the low nanomolar range (MIA PaCa-2, GI50=11 nM). |
| PC-38668 |
JHU395
Glutamine antagonist
|
JHU395 is orally-bioavailable glutamine antagonist prodrug, shows antitumor activity in malignant peripheral nerve sheath tumor (MPNST, sNF96.2 cell growth IC50=4.6 uM). |
| PC-38667 |
(S)-IBD3540
GCPII inhibitor
|
(S)-IBD3540 is a potent, gut-restricted and orally active small molecule glutamate carboxypeptidase II (GCPII) inhibitor with IC50 of 4 nM, demonstrates anti-colitis activity in both acute and chronic mouse colitis models. |
| PC-38651 |
TLK1 inhibitor J54
TLK1 inhibitor
|
TLK1 inhibitor J54 (J3-54) is a potent, small-molecule TLK1 inhibitor, induces apoptosis in AS PCa cells, suppresses growth of LNCaP xenografts combined with bicalutamide. |
| PC-38631 |
SFI003
SRSF3 inhibitor
|
SFI003 is novel serine/arginine-rich splicing factor 3 (SRSF3) inhibitor, inhibits the proliferation and migration of CRC cells, inhibits the proliferation of HCT-116 with IC50 of 8.78 uM. |
| PC-38607 |
ML-145
GPR35 inhibitor
|
ML145 (CID-2286812) is a selective GPR35 antagonist with IC50 of 20.1 nM, >1000-fold selectivity over GPR55. |
| PC-38497 |
UNC7467
IP6K inhibitor
|
UNC7467 is a potent, selective inositol hexakisphosphate kinase (IP6K) inhibitor with IC50 values of 8.9 nM (IP6K1), 4.9 nM (IP6K2) and 1320 nM (IP6K3). |
| PC-38478 |
KYP-2047
Prolyl oligopeptidase (PREP) inhibitor
|
KYP-2047 is a high affinity prolyl oligopeptidase (PREP) inhibitor with Ki of 0.023 nM, reduces α-synuclein protein levels and aggregates in cellular and animal models of PD. |
| PC-38425 |
Utreloxastat
α-synuclein inhibitor
|
Utreloxastat is a small molecule with potential for suppressing and treating α-synucleinopathies, tauopathies, and other disorders. |
| PC-38422 |
Sirpiglenastat
Glutamine antagonist
|
DRP-104 (Sirpiglenastat) is a novel broad acting glutamine antagonist, has significant anticancer activity by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response. |
