GCN2iA | GCN2 inhibitor | Probechem Biochemicals

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Chemical Structure : GCN2iA

GCN2iA (GCN2 inhibitor)

Catalog No.: PC-20842Not For Human Use, Lab Use Only.

GCN2iA is a potent seletive inhibitor of general control nonderepressible 2 (GCN2) with IC50 of 4.0 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GCN2iA is a potent seletive inhibitor of general control nonderepressible 2 (GCN2) with IC50 of 4.0 nM.
GCN2iA suppresses the phosphorylation of GCN2 and eIF2α as well as ATF4 expression in U2OS cells.
GCN2iA sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response.
GCN2iA is not suitable for in vivo use because of its poor pharmacokinetic profile

Physicochemical Properties

M.Wt	347.38
Formula	C18H17N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(3-(4-methoxyphenyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)-3-methylbenzene-1,4-diamine

References

1. Akito Nakamura, et al. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7776-E7785.

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