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Chemical Structure : GCN2iA
Catalog No.: PC-20842Not For Human Use, Lab Use Only.
GCN2iA is a potent seletive inhibitor of general control nonderepressible 2 (GCN2) with IC50 of 4.0 nM.
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GCN2iA is a potent seletive inhibitor of general control nonderepressible 2 (GCN2) with IC50 of 4.0 nM.
GCN2iA suppresses the phosphorylation of GCN2 and eIF2α as well as ATF4 expression in U2OS cells.
GCN2iA sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response.
GCN2iA is not suitable for in vivo use because of its poor pharmacokinetic profile
| M.Wt | 347.38 | |
| Formula | C18H17N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Akito Nakamura, et al. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7776-E7785.
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