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CK147

Chemical Structure : CK147

CAS No.: 1883356-12-4

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CK147 (CK-147, CK 147)

Catalog No.: PC-20794Not For Human Use, Lab Use Only.

CK147 (CK-147) is a potent CD4 down-modulator with IC50 of 63 nM, inhibits Sec61-dependent cotranslational translocation of huCD4 in vitro.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

CK147 (CK-147) is a potent CD4 down-modulator with IC50 of 63 nM, inhibits Sec61-dependent cotranslational translocation of huCD4 in vitro.
CK147 binds to a site near the plug domain and induces a partially opened conformation of Sec61.
CK147 markedly inhibits the cotranslational translocation of huCD4 in a cell-free in vitro translation assay with IC50 of 0.36 uM (HEK293T cells), with little impact on the ER import of preprolactin.

Physicochemical Properties

M.Wt 616.88
Formula C32H48N4O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=S(N1CC(CN(S(=O)(C2=CC=C(N(C)C)C=C2)=O)CCCN(CC3CCCCC3)CCC1)=C)(C4=CC=C(C)C=C4)=O

References

1. Chawla R, et al. J Med Chem. 2016 Mar 24;59(6):2633-47.

2. Eva Pauwels, et al. Sci Adv. 2023 Mar 3;9(9):eadf0797.

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