DHCR24 inhibitor SH42

Chemical Structure : DHCR24 inhibitor SH42

Catalog No.: PC-20955Not For Human Use, Lab Use Only.

DHCR24 inhibitor SH42 is a potent, selective, non-toxic delta 24-dehydrocholesterol reductase (DHCR24, Seladin-1) inhibitor, inhibits overall cholesterol biosynthesis in HL-60 cells with IC50 of 4.2 nM.

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Biological Activity

DHCR24 inhibitor SH42 is a potent, selective, non-toxic delta 24-dehydrocholesterol reductase (DHCR24, Seladin-1) inhibitor, inhibits overall cholesterol biosynthesis in HL-60 cells with IC50 of 4.2 nM.
SH42 markedly increases liver desmosterol levels and ameliorates hepatic steatosis in 3L.CETP mice fed a high-fat high-cholesterol diet (HFCD).
SH42 prevents Kupffer cell activation and reduces immune cell infiltration into the liver, does not increase circulating lipids.
The therapeutic effects of DHCR24 inhibition on hepatic steatosis are strictly dependent on LXRα, does affect circulating monocytes and neutrophils in LXRα-deficient mice.
SH42 reduces hepatic crown-like structures, liver collagen content, and plasma alanine transaminase levels in an established NAFLD model.

Physicochemical Properties

M.Wt	402.58
Formula	C25H38O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,10S,13R)-17-((S)-1-(formyloxy)propan-2-yl)-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate

References

1. Muller C,et al. Eur J Med Chem 140: 305–320.

2. Zhou E, et al. EMBO Mol Med. 2023 Jun 26:e16845.