Catalog No.: PC-20790Not For Human Use, Lab Use Only.
GO-203 (GO203) is a cell-penetrating peptide inhibitor of mucin-1-cycloplasmic C-terminal subunit (MUC1-C), blocks homodimerization of the MUC1-C subunit required for nuclear translocation and downstream signaling.
GO-203 (GO203) is a cell-penetrating peptide inhibitor of mucin-1-cycloplasmic C-terminal subunit (MUC1-C), blocks homodimerization of the MUC1-C subunit required for nuclear translocation and downstream signaling. GO-203 downregulates PI3K-Akt signaling and inhibits NSCLC cell growth. GO-203 treatment of H1975 (EGFR L858R/T790M) and A549 (K-Ras G12S) xenografts growing in nude mice resulted in tumor regressions. GO-203 is synergistic with cytotoxic agents in the treatment of breast cancer cells.
Physicochemical Properties
M.Wt
2426.77
Formula
C89H171F3N52O21S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
RRRRRRRRRCQCRRKN TFA salt
References
1. Hasegawa M, et al. Clin Cancer Res. 2015 May 15;21(10):2338-47.
2. Yin L, et al. Blood. 2014 May 8;123(19):2997-3006.
3. Raina D, et al. Mol Cancer Ther. 2011 May;10(5):806-16.
