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Chemical Structure : GO-203
CAS No.: 1222186-26-6
Catalog No.: PC-20790Not For Human Use, Lab Use Only.
GO-203 (GO203) is a cell-penetrating peptide inhibitor of mucin-1-cycloplasmic C-terminal subunit (MUC1-C), blocks homodimerization of the MUC1-C subunit required for nuclear translocation and downstream signaling.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 25 mg | $458 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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GO-203 (GO203) is a cell-penetrating peptide inhibitor of mucin-1-cycloplasmic C-terminal subunit (MUC1-C), blocks homodimerization of the MUC1-C subunit required for nuclear translocation and downstream signaling.
GO-203 downregulates PI3K-Akt signaling and inhibits NSCLC cell growth.
GO-203 treatment of H1975 (EGFR L858R/T790M) and A549 (K-Ras G12S) xenografts growing in nude mice resulted in tumor regressions.
GO-203 is synergistic with cytotoxic agents in the treatment of breast cancer cells.
| M.Wt | 2426.77 | |
| Formula | C89H171F3N52O21S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
RRRRRRRRRCQCRRKN TFA salt |
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1. Hasegawa M, et al. Clin Cancer Res. 2015 May 15;21(10):2338-47.
2. Yin L, et al. Blood. 2014 May 8;123(19):2997-3006.
3. Raina D, et al. Mol Cancer Ther. 2011 May;10(5):806-16.
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