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SRP-001

Chemical Structure : SRP-001

CAS No.: 2290606-49-2

SRP-001 (SRP001)

Catalog No.: PC-20837Not For Human Use, Lab Use Only.

SRP-001 is a non-opioid and non-hepatotoxic small molecule ApAP analog, induces analgesia via N-arachidonoylphenolamine (AM404) formation, and generates higher amounts of AM404 than ApAP.

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    Biological Activity

    SRP-001 is a non-opioid and non-hepatotoxic small molecule ApAP analog, induces analgesia via N-arachidonoylphenolamine (AM404) formation, and generates higher amounts of AM404 than ApAP.
    SRP-001 is devoid of hepatotoxicity due to lack of NAPQI formation and protection of hepatic tight junctions integrity.
    SRP-001 has comparable analgesia in pain models, including the complete Freund's adjuvant (CFA) inflammatory von Frey.
    SRP-001 shows modulation of pain-related gene expression and cell signaling pathways, including the endocannabinoid, mechanical nociception, and fatty acid amide hydrolase (FAAH) pathways.
    SRP-001 regulates the expression of key genes encoding FAAH, 2-AG, CNR1, CNR2, TRPV4, and voltage-gated Ca2+ channel.

    Physicochemical Properties

    M.Wt 405.47
    Formula C19H23N3O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N,N-diethyl-2-(N-(2-((4-hydroxyphenyl)amino)-2-oxoethyl)sulfamoyl)benzamide

    References

    1. Hernan Bazan, et al. Res Sq. 2023 May 4;rs.3.rs-2883310.

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