Catalog No.: PC-20821Not For Human Use, Lab Use Only.
PKA inhibitor H89 (H-89 dihydrochloride) is a potent, selective cAMP-dependent protein kinase A (PKA) inhibitor with IC50 of 48 nM, weakly inhibits PKG, PKC, casein kinases.
PKA inhibitor H89 (H-89 dihydrochloride) is a potent, selective cAMP-dependent protein kinase A (PKA) inhibitor with IC50 of 48 nM, weakly inhibits PKG, PKC, casein kinases. PKA inhibitor H89 causes a dose-dependent inhibition of the forskolin-induced protein phosphorylation, with no decrease in intracellular cyclic AMP levels in PC12D cells. PKA inhibitor H89 significantly inhibits the forskolin-induced neurite outgrowth from PC12D cells. PKA inhibitor H89 (30 μM) inhibited significantly cAMP-dependent histone IIb phosphorylation activity in cell lysates but did not affect other protein phosphorylation activity. PKA inhibitor H89 significantly increases seizure latency and threshold in PTZ-treated animals.
