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PKA inhibitor H89

Chemical Structure : PKA inhibitor H89

CAS No.: 130964-39-5

PKA inhibitor H89 (H-89 dihydrochloride)

Catalog No.: PC-20821Not For Human Use, Lab Use Only.

PKA inhibitor H89 (H-89 dihydrochloride) is a potent, selective cAMP-dependent protein kinase A (PKA) inhibitor with IC50 of 48 nM, weakly inhibits PKG, PKC, casein kinases.

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Biological Activity

PKA inhibitor H89 (H-89 dihydrochloride) is a potent, selective cAMP-dependent protein kinase A (PKA) inhibitor with IC50 of 48 nM, weakly inhibits PKG, PKC, casein kinases.
PKA inhibitor H89 causes a dose-dependent inhibition of the forskolin-induced protein phosphorylation, with no decrease in intracellular cyclic AMP levels in PC12D cells.
PKA inhibitor H89 significantly inhibits the forskolin-induced neurite outgrowth from PC12D cells.
PKA inhibitor H89 (30 μM) inhibited significantly cAMP-dependent histone IIb phosphorylation activity in cell lysates but did not affect other protein phosphorylation activity.
PKA inhibitor H89 significantly increases seizure latency and threshold in PTZ-treated animals.

Physicochemical Properties

M.Wt 519.28
Formula C20H22BrCl2N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-N-(2-((3-(4-bromophenyl)allyl)amino)ethyl)isoquinoline-5-sulfonamide dihydrochloride

References

1. Hansen SH, et al. J Cell Biol. 1994 Aug;126(3):677-87.

2. Chijiwa T, et al. J Biol Chem . 1990 Mar 25;265(9):5267-72.

3. Hosseini-Zare MS, et al. Eur J Pharmacol. 2011 Nov 30;670(2-3):464-70.

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