C902 | LIN28 inhibitor | Probechem Biochemicals

Chemical Structure : C902

C902 (LIN28 inhibitor C902 )

Catalog No.: PC-20847Not For Human Use, Lab Use Only.

C902 is a small-molecule inhibitor targeting LIN28-let-7 interaction, shows dose-dependent inhibition in an EMSA validation assay with IC50 of 5 uM.

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Biological Activity

C902 is a small-molecule inhibitor targeting LIN28-let-7 interaction, shows dose-dependent inhibition in an EMSA validation assay with IC50 of 5 uM.
C902 enhanced thermal stability of the cold shock domain of LIN28, and increased mature let-7 levels in JAR cells

Physicochemical Properties

M.Wt	577.41
Formula	C27H17BrN2O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3-(4-bromobenzoyl)-4-hydroxy-5-oxo-2-(4-(thiazol-2-yl)phenyl)-2,5-dihydro-1H-pyrrol-1-yl)-2-hydroxybenzoic acid

References

1. Lydia Borgelt, et al. ACS Med Chem Lett. 2021 Jun 10; 12(6): 893–898.

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C902 (LIN28 inhibitor C902 )

Biological Activity

Physicochemical Properties

References

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