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C902

Chemical Structure : C902

CAS No.: 1395472-39-5

C902 (LIN28 inhibitor C902 )

Catalog No.: PC-20847Not For Human Use, Lab Use Only.

C902 is a small-molecule inhibitor targeting LIN28-let-7 interaction, shows dose-dependent inhibition in an EMSA validation assay with IC50 of 5 uM.

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    Biological Activity

    C902 is a small-molecule inhibitor targeting LIN28-let-7 interaction, shows dose-dependent inhibition in an EMSA validation assay with IC50 of 5 uM.
    C902 enhanced thermal stability of the cold shock domain of LIN28, and increased mature let-7 levels in JAR cells

    Physicochemical Properties

    M.Wt 577.41
    Formula C27H17BrN2O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-(3-(4-bromobenzoyl)-4-hydroxy-5-oxo-2-(4-(thiazol-2-yl)phenyl)-2,5-dihydro-1H-pyrrol-1-yl)-2-hydroxybenzoic acid

    References

    1. Lydia Borgelt, et al. ACS Med Chem Lett. 2021 Jun 10; 12(6): 893–898.

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