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C902

Chemical Structure : C902

CAS No.: 1395472-39-5

C902 (LIN28 inhibitor C902 )

Catalog No.: PC-20847Not For Human Use, Lab Use Only.

C902 is a small-molecule inhibitor targeting LIN28-let-7 interaction, shows dose-dependent inhibition in an EMSA validation assay with IC50 of 5 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

C902 is a small-molecule inhibitor targeting LIN28-let-7 interaction, shows dose-dependent inhibition in an EMSA validation assay with IC50 of 5 uM. enhanced thermal stability of the cold shock domain of LIN28, and increased mature let-7 levels in JAR cells

Physicochemical Properties

M.Wt 577.41
Formula C27H17BrN2O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

O=C(O)C1=CC(N2C(C3=CC=C(C4=NC=CS4)C=C3)C(C(C5=CC=C(Br)C=C5)=O)=C(O)C2=O)=CC=C1O

References

1. Lydia Borgelt, et al. ACS Med Chem Lett. 2021 Jun 10; 12(6): 893–898.

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