| Cat. No. |
Product Name |
Information |
| PC-21626 |
PQ912
Glutaminyl cyclase inhibitor
|
Varoglutamstat (PQ912) is a potent glutaminyl cyclase (QC) inhibitor with Ki values of 20-65 nM for human, rat, and mouse QC activity. |
| PC-21576 |
PCC0105003
MARK inhibitor
|
PCC0105003 is a small molecule microtubule affinity-regulating kinases (MARKs) inhibitor with IC50 of 3.0, 2.0, 2.67 and 2.67 nM for MARK1, 2, 3 and 4 repectively. |
| PC-21575 |
BiTud
TDRD3 inhibitor
|
BiTud is a bivalent inhibitor against TDRD3 with binding Kd of 6 uM for tandem Tudor chimera, blocks the recruitment of TDRD3 by the two methylated arginines of G3BP1, suppress the phase separation of methylated G3BP1, TDRD3, and RNAs, and in turn inhibits the stress granule growth in cells. |
| PC-21523 |
DS68591889
PTDSS1 inhibitor
|
DS68591889 (PTDSS1i) is a potent, selective phosphatidylserine synthase 1 (PTDSS1) inhibitor, highly sellective over PTDSS2, induces phospholipid imbalance in a wide range of cancer cells. |
| PC-21416 |
HQY426
CPSF3 inhibitor
|
HQY426 is a specific, orally bioavailable inhibitor of pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3) with binding IC50 of 0.32 uM, exhibits potent antitumor activity. |
| PC-21410 |
LY3522348
Ketohexokinase (KHK) inhibitor
|
LY3522348 is a potent, highly selective, oral dual inhibitor of human ketohexokinase isoforms C and A (hKHK-C, hKHK-A) with IC50 of 20 nM and 24 nM, respectively. |
| PC-21385 |
PXS-5505 dihydrochloride monohydrate
pan-LOX inhibitor
|
PXS-5505 dihydrochloride monohydrate is an orally available, small-molecule, irreversible inhibitor of all lysyl oxidases (pan-LOX) family members, with potential antifibrotic activity. |
| PC-21363 |
IGF2BP3 inhibitor AE-848
IGF2BP3 inhibitor
|
IGF2BP3 inhibitor AE-848 is a small molecule inhibitor of RNA m6A reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), inhibits the growth and progression of OC cells by disrupting the stability of the targeted mRNAs of IGF2BP3. |
| PC-21350 |
IP-DNQ
NQO1 inhibitor
|
IP-DNQ (Isopentyl-deoxynboquinone) is a small molecule that selectively kills pancreatic ductal adenocarcinoma cells in an NQO1-dependent manner. |
| PC-21347 |
Karyostatin 1A
Importin β inhibitor
|
Karyostatin 1A is a small molecule inhibitor of importin beta with binding affinity (Kd=0.3 uM), selectively inhibits the importin α/β pathway. |
| PC-21299 |
2-MPPA
GCP-II Inhibitor
|
2-MPPA (GPI-5693) is a potent, selective and orally active glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor with IC50 of 90 nM. |
| PC-21294 |
NVS1.1
Readthrough promoter
|
NVS1.1 is a potent readthrough promoter, promotes the rapid and specific degradation of eukaryotic release factor 1 (eRF1) and restores functional full-length proteins in cystic fibrosis and Hurler disease models. |
