| Cat. No. |
Product Name |
Information |
| PC-23494 |
Ibetazol
Importin β inhibitor
|
Ibetazol is novel specific small molecule inhibitor of importin β1 (KPNB1)-mediated nuclear import with EC50 of 6.3 uM in phenotypic importin α1 translocation assays , binds to cysteine 585 of importin β1. |
| PC-23451 |
PF-07328948
BDK inhibitor
|
PF-07328948 is the first potent, selective branched-chain ketoacid dehydrogenase kinase (BDK or BCKDK) with in vitro IC50 of 15 nM, and cellular IC50 of 46 nM in human skeletal muscle BDK activity assay. |
| PC-23304 |
PGMI-004A
PGAM1 inhibitor
|
PGMI-004A is a specific small molecule inhibitor of glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) with IC50 of 13.1 uM, Ki of 3.91 uM. |
| PC-23229 |
SLCB050
DX2-p14/ARF inhibitor
|
SLCB050 is a specific small molecule inhibitor of AIMP2-DX2-p14/ARF Interaction, inhibits lung cancer progression. |
| PC-23228 |
AM-001
EPAC1 inhibitor
|
AM-001 is a potent, selective and allosteric inhibitor of exchange proteins directly activated by cAMP 1 (EPAC1), inhibits Sp-8-CPT-induced Epac1 (EC50=47.8 uM) but not Epac2 activity. |
| PC-23227 |
Tirasemtiv
Fast skeletal troponin activator
|
Tirasemtiv (CK-2017357) is the first activator of fast skeletal muscle troponin with AC40 of 0.1 uM in in myofibril ATPase activity assays, shows potential for the treatment of amyotrophic lateral sclerosis. |
| PC-23069 |
QC-308
Heme oxygenase inhibitor
|
QC-308 is a potent heme oxygenase (HO) inhibitor witn IC50 of 0.27 uM and 0.46 uM for hHO-1 and hHO-2 respectively. |
| PC-22980 |
Peptide SBT-20
ROS-lowering peptide
|
Peptide SBT-20 (SS-20) is a cell-permeable peptide targeting the inner mitochondrial membrane, reduces ROS, normalizes electron transport chain function and ATP generation. |
| PC-22641 |
TAK-448
KISS1R agonist
|
TAK-448 (MVT-602) is a potent and full KISS1R (metastin receptor) agonist and kisspeptin analogue with IC50 of 3 pM in radioimmunoassay. |
| PC-22534 |
TSLP inhibitor BP79
TSLP inhibitor
|
TSLP inhibitor BP79 is a specific small molecule inhibitor of thymic stromal lymphopoietin (TSLP), disrupts TSLP-TSLP receptor interaction and effectively abrogates TSLP-triggered cytokines at low micromolar concentrations. |
| PC-22494 |
CCG-1423
MKL1 inhibitor
|
CCG-1423 (CCG1423) is a small-molecule inhibitor of RhoA transcriptional signaling and serum response factor (SRF), blocks transcription activated by MKL1, disrupts transcriptional responses of the Rho pathway in cancer. |
| PC-22469 |
BI-43
Glutaminyl cyclase inhibitor
|
BI-43 is a potent, selective glutaminyl cyclase inhibitor with IC50 of 12 nM and 40 nM for both sQC and gQC, respectively. |
