| Cat. No. |
Product Name |
Information |
| PC-28329 |
BBP-671
PANK3 activator
|
Claziprotamide (BBP-671) is a potent, brain penetrant small molecule activator of Pantothenate kinase (PanK) with Kd of 97 pM and IC50 of 1.59 nM for PanK3, binds to and activates all PANK isoforms. |
| PC-28328 |
PZ-3022
PANK3 activator
|
PZ-3022 is an allosteric, orally bioavailable Pantothenate kinase (PanK) activator with EC50 of 5.3 nM against PanK3, shows a lower affinity for PanK isoforms PANK1β and PANK2m with EC50 of 789 nM and 15 nM respectively. |
| PC-28327 |
VTAC-2
PANK3 activator
|
VTAC-2 is a specific, direct small molecule activator of human PANK3 (Pantothenate kinase 3) with EC50 of 76.5 nM, shows no effect on the catalytic activity of hPANK1 or hPANK2. |
| PC-28234 |
Cytochalasin D
Actin polymerization inhibitor
|
Cytochalasin D (Zygosporin A, CytoD) is a specific inhibitor of actin polymerization, inhibits the G-actin-cofilin interaction by binding to G-actin, also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. |
| PC-28217 |
AIGM-2024-4
YB-1 modulator
|
AIGM-2024-4 is a small molecule modulator of Y-Box Binding Protein-1 (YB-1, YBX-1) with MST KD of 1.24 uM, significantly reduces tumor growth in DMBA- induced rat mammary tumor model, accompanied by altered expression of YB-1 and tumor progression associated proteins, including HER2, EGFR, ERα, and Ki-67, together with increased E-cadherin expression. |
| PC-28178 |
Naringenin
DENV RdRp inhibitor, MARK4 inhibitor
|
Naringenin is a flavanone in Citrus reticulata Blanco within anti-inflammatory and antioxidant activities, monocarboxylate transporter 1 (MCT1) in Caco-2 cells with Ki of 15-20 uM, also inhibits DENV RNA-dependent RNA polymerase (RdRp), is also a potent inhibitor of MARK4 with IC50 of 4.11 uM. |
| PC-28165 |
B1486
VprBP inhibitor
|
B1486 is a highly potent, specific VprBP inhibitor with IC50 of 3.8 nM, inhibits VprBP-driven osteoclastogenesis and H2AT120p. |
| PC-28153 |
QP6126
QPCTL inhibitor
|
QP6126 is a highly potent, orally bioavailable inhibitor of Glutaminyl-peptide cyclotransferase-like protein (QPCTL) with IC50 of 2.3 nM. |
| PC-28132 |
TNG-2673
MGAT1 inhibitor
|
TNG-2673 is a potent, selective, allosteric inhibitor of Golgi glycosyltransferase MGAT1 with IC50 of 43 nM, inhibits MGAT1 through a UDP-noncompetitive mechanism. |
| PC-28116 |
SMC247-9 hydrochloride
APOBEC3B inhibitor
|
SMC247-9 hydrochloride is a highly potent inhibitor of single-stranded DNA cytosine-to-uracil deaminase APOBEC3B (A3B) inhibitor with IC50 of 50 pM and MST KD of 300 pM. |
| PC-28115 |
SMC247-9
APOBEC3B inhibitor
|
SMC247-9 is a highly potent inhibitor of single-stranded DNA cytosine-to-uracil deaminase APOBEC3B (A3B) inhibitor with IC50 of 50 pM and MST KD of 300 pM. |
| PC-28103 |
TXNIP-IN-1
TXNIP inhibitor
|
TXNIP-IN-1 is a small molecule thioredoxin-thioredoxin-interacting-protein (TXNIP-TRX) complex inhibitor. |
