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Cat. No. Product Name Information
PC-23529

ARI-1

ROR1 inhibitor

ARI-1 is a specific inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1), directly targets the frizzled domain with high binding affinity, inhibits EGFR-TKIs-resisted NSCLC with high ROR1 expression.
PC-23519

Necrocide 1

Necrosis inducer, TRPM4 activator

Necrocide 1 (NC1) is a small molecule inducer of tumor necrosis factor (TNF)-independent necrosis, shows antiproliferative activity with IC50 values of 0.48 and 2 nM for MCF-7 and PC3, respectively.
PC-23517

ATX968

DHX9 inhibitor

ATX968 is a potent and selective inhibitor of DHX9 helicase activity with DHX9 unwinding IC50 of 8 nM, SPR Kd value of 1.3 nM.
PC-23494

Ibetazol

Importin β inhibitor

Ibetazol is novel specific small molecule inhibitor of importin β1 (KPNB1)-mediated nuclear import with EC50 of 6.3 uM in phenotypic importin α1 translocation assays , binds to cysteine 585 of importin β1.
PC-23451

PF-07328948

BDK inhibitor

PF-07328948 is the first potent, selective branched-chain ketoacid dehydrogenase kinase (BDK or BCKDK) with in vitro IC50 of 15 nM, and cellular IC50 of 46 nM in human skeletal muscle BDK activity assay.
PC-23325

Stomidazolone

Stomatal differentiation inhibitor

Stomidazolone is a doubly-sulfonylated imidazolone that inhibits stomatal differentiation, tightly binds to C-terminal ACT-Like (ACTL) domain of MUTE (Kd=8.9 uM) and perturbs the SCRM-MUTE heterodimerization.
PC-23304

PGMI-004A

PGAM1 inhibitor

PGMI-004A is a specific small molecule inhibitor of glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) with IC50 of 13.1 uM, Ki of 3.91 uM.
PC-23229

SLCB050

DX2-p14/ARF inhibitor

SLCB050 is a specific small molecule inhibitor of AIMP2-DX2-p14/ARF Interaction, inhibits lung cancer progression.
PC-23228

AM-001

EPAC1 inhibitor

AM-001 is a potent, selective and allosteric inhibitor of exchange proteins directly activated by cAMP 1 (EPAC1), inhibits Sp-8-CPT-induced Epac1 (EC50=47.8 uM) but not Epac2 activity.
PC-23227

Tirasemtiv

Fast skeletal troponin activator

Tirasemtiv (CK-2017357) is the first activator of fast skeletal muscle troponin with AC40 of 0.1 uM in in myofibril ATPase activity assays, shows potential for the treatment of amyotrophic lateral sclerosis.
PC-23069

QC-308

Heme oxygenase inhibitor

QC-308 is a potent heme oxygenase (HO) inhibitor witn IC50 of 0.27 uM and 0.46 uM for hHO-1 and hHO-2 respectively.
PC-22980

Peptide SBT-20

ROS-lowering peptide

Peptide SBT-20 (SS-20) is a cell-permeable peptide targeting the inner mitochondrial membrane, reduces ROS, normalizes electron transport chain function and ATP generation.

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