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Chemical Structure : AM-001
Catalog No.: PC-23228Not For Human Use, Lab Use Only.
AM-001 is a potent, selective and allosteric inhibitor of exchange proteins directly activated by cAMP 1 (EPAC1), inhibits Sp-8-CPT-induced Epac1 (EC50=47.8 uM) but not Epac2 activity.
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AM-001 is a potent, selective and allosteric inhibitor of exchange proteins directly activated by cAMP 1 (EPAC1), inhibits Sp-8-CPT-induced Epac1 (EC50=47.8 uM) but not Epac2 activity.
AM-001 shows .no antagonist effect on Epac2 or protein kinase A activity.
AM-001 prevents the activation of the Epac1 downstream effector Rap1 in cultured cells, in response to the Epac1 preferential agonist, 8-CPT-AM.
AM-001 reduces infarct size after mouse myocardial ischaemia/reperfusion injury. attenuates cardiac hypertrophy, inflammation and fibrosis, and improves cardiac function during chronic β-adrenergic receptor activation with isoprenaline (ISO) in mice.
| M.Wt | 445.53 | |
| Formula | C24H16FN3OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bufano M, et al. J Comput Aided Mol Des. 2020 Nov;34(11):1171-1179.
2. Laudette M, et al. Cardiovasc Res. 2019 Oct 1;115(12):1766-1777.
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