Catalog No.: PC-23530Not For Human Use, Lab Use Only.
LDR102 (ROR1 inhibitor 19h) is a potent, specfic inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with SPR KD of 100 nM, binds the intracellular kinase domain and inhibits ROR1 kinase activity.
LDR102 (ROR1 inhibitor 19h) is a potent, specfic inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with SPR KD of 100 nM, binds the intracellular kinase domain and inhibits ROR1 kinase activity.
LDR102 exhibits antitumor activity in lung cancer and breast cancer cell lines (IC50: 0.36-1.37 μM).
LDR102 induces the apoptosis of tumor cells.
LDR102 significantly suppressed tumor growth in a mouse model without obvious toxicity.
