Catalog No.: PC-23555Not For Human Use, Lab Use Only.
R162 is a potent, specific inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1) with Ki of 28.6 uM, inhibits cancer cell proliferation and tumor growth.
R162 is a potent, specific inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1) with Ki of 28.6 uM, inhibits cancer cell proliferation and tumor growth. R162 treatment results in decreased intracellular fumarate levels, attenuated GPx activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells. R162 shows promising anti-proliferative potential in cancer cells with minimal toxicity in vitro and in vivo.
Physicochemical Properties
M.Wt
264.28
Formula
C17H12O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-Allyl-1-hydroxy-9,10-anthraquinone
References
1. Jin L, et al. Cancer Cell. 2015 Feb 9;27(2):257-70.
2. Jin L, et al. Mol Cell. 2018 Jan 4;69(1):87-99.e7.
