Chemical Structure : Tirasemtiv
CAS No.: 1005491-05-3
Catalog No.: PC-23227Not For Human Use, Lab Use Only.
Tirasemtiv (CK-2017357) is the first activator of fast skeletal muscle troponin with AC40 of 0.1 uM in in myofibril ATPase activity assays, shows potential for the treatment of amyotrophic lateral sclerosis.
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Tirasemtiv (CK-2017357) is the first activator of fast skeletal muscle troponin with AC40 of 0.1 uM in in myofibril ATPase activity assays, shows potential for the treatment of amyotrophic lateral sclerosis.
M.Wt | 230.27 | |
Formula | C12H14N4O | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
5-ethynyl-3-pentan-3-yl-1H-imidazo[4,5-b]pyrazin-2-one |
1. Lutz AK, et al. Sci Transl Med. 2020 Jun 10;12(547):eaaz3267.
2. Collibee SE, et al. ACS Med Chem Lett. 2018 Feb 13;9(4):354-358.
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