Tirasemtiv | Fast skeletal troponin activator

Chemical Structure : Tirasemtiv

CAS No.: 1005491-05-3

Tirasemtiv (CK-2017357, CK2017357)

Catalog No.: PC-23227Not For Human Use, Lab Use Only.

Tirasemtiv (CK-2017357) is the first activator of fast skeletal muscle troponin with AC40 of 0.1 uM in in myofibril ATPase activity assays, shows potential for the treatment of amyotrophic lateral sclerosis.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
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Biological Activity

Tirasemtiv (CK-2017357) is the first activator of fast skeletal muscle troponin with AC40 of 0.1 uM in in myofibril ATPase activity assays, shows potential for the treatment of amyotrophic lateral sclerosis.

Physicochemical Properties

M.Wt	230.27
Formula	C12H14N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-ethynyl-3-pentan-3-yl-1H-imidazo[4,5-b]pyrazin-2-one

References

1. Lutz AK, et al. Sci Transl Med. 2020 Jun 10;12(547):eaaz3267.

2. Collibee SE, et al. ACS Med Chem Lett. 2018 Feb 13;9(4):354-358.

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Tirasemtiv (CK-2017357, CK2017357)

Biological Activity

Physicochemical Properties

References

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