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Tirasemtiv

Chemical Structure : Tirasemtiv

CAS No.: 1005491-05-3

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Tirasemtiv (CK-2017357, CK2017357)

Catalog No.: PC-23227Not For Human Use, Lab Use Only.

Tirasemtiv (CK-2017357) is the first activator of fast skeletal muscle troponin with AC40 of 0.1 uM in in myofibril ATPase activity assays, shows potential for the treatment of amyotrophic lateral sclerosis.

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10 mg $128 In stock
25 mg $218 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Tirasemtiv (CK-2017357) is the first activator of fast skeletal muscle troponin with AC40 of 0.1 uM in in myofibril ATPase activity assays, shows potential for the treatment of amyotrophic lateral sclerosis.

Physicochemical Properties

M.Wt 230.27
Formula C12H14N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-ethynyl-3-pentan-3-yl-1H-imidazo[4,5-b]pyrazin-2-one

References

1. Lutz AK, et al. Sci Transl Med. 2020 Jun 10;12(547):eaaz3267.

2. Collibee SE, et al. ACS Med Chem Lett. 2018 Feb 13;9(4):354-358.

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