ARI-1

Chemical Structure : ARI-1

Catalog No.: PC-23529Not For Human Use, Lab Use Only.

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Biological Activity

ARI-1 is a specific inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1), directly targets the frizzled domain with high binding affinity, inhibits EGFR-TKIs-resisted NSCLC with high ROR1 expression.
ARI-1 inhibits cell proliferation and induces apoptosis by blocking PI3K/AKT/mTOR pathway.
ARI-1 suppresses cell migration in a ROR1-dependent manner in NSCLC cells.
ARI-1 (5 mg/kg) suppresses NSCLC tumor growth without obvious toxicity.

Physicochemical Properties

M.Wt	374.39
Formula	C20H22O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5,7-bis(methoxymethoxy)-2-(4-methoxyphenyl)chroman-4-one

References

1. Liu X, et al. Cancer Lett. 2019 Aug 28,458:76-85.

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ARI-1

Biological Activity

Physicochemical Properties

References

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