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Chemical Structure : PGMI-004A
CAS No.: 1313738-90-7
Catalog No.: PC-23304Not For Human Use, Lab Use Only.
PGMI-004A is a specific small molecule inhibitor of glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) with IC50 of 13.1 uM, Ki of 3.91 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
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| 100 mg | Get quote |
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PGMI-004A is a specific small molecule inhibitor of glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) with IC50 of 13.1 uM, Ki of 3.91 uM.
PGMI-004A directly binds to the protein with KD of 9.4 uM.
PGMI-004A treatment results in decreased 2-PG and increased 3-PG levels in H1299 cells, which could be rescued by treatment with methyl-2-PG.
PGMI-004A treatment results in decreased oxidative PPP flux and NADPH/NADP+ ratio as well as reduced biosynthesis of lipids and RNA and cell proliferation in H1299 cells.
PGMI-004A treatment inhibits cancer cell proliferation and tumor growth, and alters 3-PG and 2-PG levels in primary leukemia cells from human patients, leading to attenuated leukemia cell proliferation.
| M.Wt | 463.38 | |
| Formula | C21H12F3NO6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3,4-dihydroxy-9,10-dioxo-N-(4-(trifluoromethyl)phenyl)-9,10-dihydroanthracene-2-sulfonamide |
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1. Hitosugi T, et al. Cancer Cell. 2012 Nov 13;22(5):585-600.
2. Wang P, et al. Bioorg Med Chem. 2018 May 1;26(8):1961-1970.
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