| Cat. No. |
Product Name |
Information |
| PC-35479 |
Padsevonil
SV2 ligand
|
Padsevonil (UCB0942) is an antiepileptic drug (AED) candidate with high affinity for synaptic vesicle 2 (SV2) proteins with pKi of 8.5/7.9/8.5 for SV2A/SV2B/SV2C, respectively. |
| PC-35466 |
Soticlestat
CH24H inhibitor
|
Soticlestat (TAK-935) is a potent, selective, orally active inhibitor for Cholesterol 24-hydroxylase (CH24H) with IC50 of 7.4 nM. |
| PC-35460 |
ATR-101 free base
ACAT1 inhibitor
|
ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM. |
| PC-35451 |
Foslinanib sodium
TRAP1 inhibitor
|
Foslinanib (TRX-818, CVM-1118) sodium is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1. |
| PC-35441 |
Cimlanod
HNO donor
|
Cimlanod is a second-generation nitroxyl (HNO) donor, delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream, shows positive lusitropic and inotropic as well as vasodilatory effects. |
| PC-35430 |
BIO124
PICK1-GluA2 inhibitor
|
BIO124 (BIO-124) is a modest inhibitor of the PICK1-GluA2 interaction with IC50 of 0.51 uM in FP assays, binds to the PDZ domain of PICK1. |
| PC-35415 |
Desmethyl dabrafenib
|
Desmethyl dabrafenib (GSK2167542, Dabrafenib metabolite M8) is the desmethyl- metabolic byproduct of Dabrafenib, ameliorates developmental pathologies of Kabuki Syndrome in vivo.. |
| PC-35412 |
GAK inhibitor 49
GAK inhibitor
|
GAK inhibitor 49 is a potent, selective, ATP-competitive inhibitor of cyclin G-associated kinase (GAK, cell IC50=56 nM) with favourable NAK family selectivity (AAK1, STK16, BMP2K). |
| PC-35411 |
GAK inhibitor 12r
GAK inhibitor
|
GAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM. |
| PC-35410 |
IGS-1.76
NCS-1/Ric8a inhibitor
|
IGS-1.76 is a small molecule inhibitor of human NCS-1/Ric8a interaction with affinity of 1.25 uM (hNCS-1). |
| PC-35386 |
FTBMT
GPR52 agonist
|
FTBMT (TP024) is a novel selective GPR52 agonist, increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50 of 7.03, 6.85, and 6.87M, respectively. |
| PC-35376 |
SOD1-Derlin-1 inhibitor 56-59
|
SOD1-Derlin-1 inhibitor 56-59 is a cell-permeable, small molecule inhibitor of SOD1-Derlin-1 interaction, target SOD1 DBR and clearly attenuates the interactions of Derlin-1 with 122 types of SOD1mut in the cell-based co-immunoprecipitation assays. |
