| Cat. No. |
Product Name |
Information |
| PC-35607 |
P053
CerS1 inhibitor
|
P053 (P-053, CerS1 inhibitor P053) is a potent, selective, orally active inhibitor of ceramide synthase 1 (CerS1) with IC50 of 0.5 uM, displays >10-fold selectivity for inhibition of CerS2, CerS4, CerS5, and CerS6. |
| PC-35588 |
CTPI-2
SLC25A1 inhibitor
|
CTPI-2 (SLC25A1 inhibitor CTPI-2) is a novel specific SLC25A1 inhibitor with Kd of 3.5 uM, CTPI-2 is synthetic lethal with cisplatin or with EGFR inhibitor co-treatment and restores antitumor responses both in vitro and in vivo. |
| PC-35586 |
MAI-150
APC-Asef inhibitor
|
MAI-150 is a peptidomimetic inhibitor of APC-Asef interaction, blocks colorectal cancer migration.. |
| PC-35583 |
NP161
Thioredoxin 1 inhibitor
|
NP161 is a potent and selective inhibitor of extracellular TRX (Thioredoxin 1) in vitro with IC50 of 0.54 uM. |
| PC-35582 |
MFN2 agonist B-A l
MFN2 agonist
|
MFN2 agonist B-A l is a mall-molecule mimics of the peptide-peptide interface of MFN2, allosterically activates MFN2 and promotes mitochondrial fusion with EC50 of 3 nM. |
| PC-35569 |
MAI-400
APC-Asef inhibitor
|
MAI-400 (MAI400) is a novel peptide inhibitor of APC-Asef interaction with Kd of 12 nM and IC50 of 0.25 uM. |
| PC-35568 |
NGI-1 derivative C-19
OST inhibitor
|
NGI-1 derivative C-19 is a specific, small-molecule inhibitor of oligosaccharyltransferase (OST) catalytic subunit STT3B, without effect on STT3A. |
| PC-35563 |
APX2014
Ref-1/APE1 inhibitor
|
APX2014 (APX-2014) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.2 uM for redox EMSA inhibition. |
| PC-35561 |
Aminopyridine 2
MPO inhibitor
|
Aminopyridine 2 (MPO inhibitor AP-2) is a novel potent, selective, orally available inhibitor of Myeloperoxidase (MPO), inhibits MPO peroxidase activity in vitro and in human plasma with IC50 of 0.16 and 1.9 uM, respectively. |
| PC-35538 |
AF64394
GPR3 inverse agonist
|
AF64394 is a potent, selective GPR3 inverse agonist with pIC50 of 7.3, displays >100-fold selectivity over GPR6 and GPR12. |
| PC-35530 |
MID-1
MG53-IRS-1 inhibitor
|
MID-1 (ChemBridge5655896) is a specific small molecule MG53-IRS-1 interaction disruptor (MID), but not MG53-FAK and-Cav-3 interaction. |
| PC-35527 |
Qstatin
|
Qstatin is a potent SmcR inhibitor in V. vulnificus. with IC50 of 208.9 nM, shows pan-QS (quorum sensing) inhibitor activity in diverse Vibrio species. |
