| Cat. No. |
Product Name |
Information |
| PC-35563 |
APX2014
Ref-1/APE1 inhibitor
|
APX2014 (APX-2014) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.2 uM for redox EMSA inhibition. |
| PC-35561 |
Aminopyridine 2
MPO inhibitor
|
Aminopyridine 2 (MPO inhibitor AP-2) is a novel potent, selective, orally available inhibitor of Myeloperoxidase (MPO), inhibits MPO peroxidase activity in vitro and in human plasma with IC50 of 0.16 and 1.9 uM, respectively. |
| PC-35538 |
AF64394
GPR3 inverse agonist
|
AF64394 is a potent, selective GPR3 inverse agonist with pIC50 of 7.3, displays >100-fold selectivity over GPR6 and GPR12. |
| PC-35530 |
MID-1
MG53-IRS-1 inhibitor
|
MID-1 (ChemBridge5655896) is a specific small molecule MG53-IRS-1 interaction disruptor (MID), but not MG53-FAK and-Cav-3 interaction. |
| PC-35527 |
Qstatin
|
Qstatin is a potent SmcR inhibitor in V. vulnificus. with IC50 of 208.9 nM, shows pan-QS (quorum sensing) inhibitor activity in diverse Vibrio species. |
| PC-35500 |
NMac1
Nm23/NDPK activator
|
NMac1 (Nm23 activator 1) is a small molecule activator of Nm23/NDPK, directly binds to Nm23-H1 and activates NDPK activity of recombinant Nm23-H1 with EC50 of 10.7 uM. |
| PC-35499 |
CFM-4.16
CARP-1 inducer
|
CFM-4.16 is a CARP-1 functional mimetic (CFM) compound bind with CARP-1, stimulates CARP-1 expression and apoptosis. |
| PC-35481 |
JNJ-26489112
Anticonvulsant agent
|
JNJ-26489112 (JNJ26489112) is a broad-spectrum anticonvulsant that displays activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures. |
| PC-35479 |
Padsevonil
SV2 ligand
|
Padsevonil (UCB0942) is an antiepileptic drug (AED) candidate with high affinity for synaptic vesicle 2 (SV2) proteins with pKi of 8.5/7.9/8.5 for SV2A/SV2B/SV2C, respectively. |
| PC-35466 |
Soticlestat
CH24H inhibitor
|
Soticlestat (TAK-935) is a potent, selective, orally active inhibitor for Cholesterol 24-hydroxylase (CH24H) with IC50 of 7.4 nM. |
| PC-35460 |
ATR-101 free base
ACAT1 inhibitor
|
ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM. |
| PC-35451 |
Foslinanib sodium
TRAP1 inhibitor
|
Foslinanib (TRX-818, CVM-1118) sodium is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1. |
