| Cat. No. |
Product Name |
Information |
| PC-35205 |
IACS-010759
OXPHOS inhibitor
|
IACS-010759 (IACS010759) is a small molecule inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targets complex I of the mitochondrial electron transport chain. |
| PC-35201 |
LIN28 inhibitor LI71
LIN28 inhibitor
|
LIN28 inhibitor LI71 is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 7 uM, binds the cold shock domain to suppress LIN28's activity against let-7 in leukemia cells and embryonic stem cells. |
| PC-35176 |
Ac-IEPD-CHO
Granzyme B inhibitor
|
Ac-IEPD-CHO is a potent, reversible inhibitor of serine protease Granzyme B (GzmB) with Ki of 80 nM, also inhibits caspase-7 (Ki=550 nM) and induces apoptosis. |
| PC-35175 |
VTI-1002
Granzyme B inhibitor
|
VTI-1002 is a first-in-class, highly potent, selective inhibitor of human Granzyme B (GzmB) with Ki of 4.4 nM, exhibits strong selectivity for GzmB over caspases 3-10, cathepsin G, and neutrophil elastase. |
| PC-35134 |
AA147
ATF6 agonist
|
AA147 is a specific, small molecule agonist of transcription factor ATF6, activates ATF6 and influences differentiation of stem cells. |
| PC-35109 |
BTZO-15
HO-1 inducer
|
BTZO-15 is an active BTZO-1 derivative for ARE-activation with a favorable ADME-Tox profile, induces expression of heme oxygenase-1 (HO-1) and inhibits NO-induced cell death in IEC-18 cells. |
| PC-35108 |
BTZO-2
MIF activator
|
BTZO-2 is an active BTZO-1 derivative and macrophage migration inhibitory factor (MIF) activator, an antioxidant response element (ARE) activator, provides protection against lethal endotoxic shock in mice. |
| PC-35107 |
BTZO-1
MIF activator, HO-1 inducer
|
BTZO-1 is a cardioprotective agent and Macrophage migration inhibitory factor (MIF) activator, binds to MIF with Kd of 68.6 nM, regulates ARE-mediated gene expression. |
| PC-35091 |
JI051
Hes1 inhibitor
|
JI051(JI-051) is a specific compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression. |
| PC-35071 |
YC-001
Rod opsin antagonist
|
YC-001 is a novel pharmacological chaperone of rod photoreceptor opsin, rescues the transport of multiple rod opsin mutants in mammalian cells, an inverse agonist and antagonist of rod opsin. |
| PC-63570 |
Siomycin A
FOXM1 inhibitor
|
Siomycin A (NSC 285116) is an antibiotic thiazole inhibitor of the oncogenic transcription factor FOXM1, down-regulates the transcriptional activity as well as the protein and mRNA abundance of FoxM1. |
| PC-63556 |
DS-2330
|
DS-2330 is a phosphorous lowering agent for treating hyperphosphatemia in chronic kidney disease.. |
