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iGOT1-01

Chemical Structure : iGOT1-01

CAS No.: 882256-55-5

iGOT1-01

Catalog No.: PC-35823Not For Human Use, Lab Use Only.

iGOT1-01 is a small molecule inhibitor of aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1 (GOT1)) with IC50 of 11.3 uM.

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Biological Activity

iGOT1-01 is a small molecule inhibitor of aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1 (GOT1)) with IC50 of 11.3 uM.
Inhibition of GOT1 preferentially leads to accumulation of the M+4 aspartate isotopologue from 13C-glutamine in pancreatic cancer cells

Physicochemical Properties

M.Wt 320.396
Formula C19H20N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide

References

1. Holt MC, et al. Biochemistry. 2018 Nov 12. doi: 10.1021/acs.biochem.8b00914.

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