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Chemical Structure : PTC299
CAS No.: 1256565-36-2
Catalog No.: PC-35755Not For Human Use, Lab Use Only.
Emvododstat (PTC-299) is a novel potent inhibitor of dihydroorotate dehydrogenase (DHODH), inhibits hypoxia-induced VEGFA protein production in HeLa cells with IC50 of 1.64 nM.
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|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
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| 100 mg | Get quote |
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Emvododstat (PTC-299) is a novel potent inhibitor of dihydroorotate dehydrogenase (DHODH), inhibits hypoxia-induced VEGFA protein production in HeLa cells with IC50 of 1.64 nM.
PTC299 inhibited DHODH activity more potently than teriflunomide and with potency similar to that of brequinar.
PTC299 demonstrates broad and potent activity against hematological cancer cells in preclinical models, inhibits AML patient-derived cells with IC50 of 2-60 nM.
PTC299 demonstrates advantages over previously reported DHODH inhibitors, including greater potency, good oral bioavailability and lack of off-target kinase inhibition and myelosuppression.
| M.Wt | 467.346 | |
| Formula | C25H20Cl2N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO (46.7 mg/mL, ultrasonic needed) |
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| Chemical Name/SMILES |
4-chlorophenyl (S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxylate |
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1. Cao L, et al. Mol Cancer Ther. 2018 Oct 23. pii: molcanther.0863.2018.
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