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Malic Enzyme inhibitor ME1

Chemical Structure : Malic Enzyme inhibitor ME1

CAS No.: 522649-59-8

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Malic Enzyme inhibitor ME1 (ME1)

Catalog No.: PC-35817Not For Human Use, Lab Use Only.

Malic Enzyme inhibitor ME1 (ME1) is a small molecule inhibitor of Malic Enzyme (ME1) with IC50 of 0.15 uM.

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5 mg $128 In stock
10 mg $198 In stock
25 mg $328 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Malic Enzyme inhibitor ME1 (ME1) is a small molecule inhibitor of Malic Enzyme (ME1) with IC50 of 0.15 uM.
ME1 suppresses growth of human CRC cells in vitro, with little effect on normal rat intestinal epithelial cells.

Physicochemical Properties

M.Wt 351.406
Formula C20H21N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-[4-(4-hydroxyphenyl)piperazin-1-yl]-1-phenylpyrrolidine-2,5-dione

References

1. Zhang YJ, et al. Bioorg Med Chem Lett. 2006 Feb;16(3):525-8.

2. Fernandes LM, et al. Sci Rep. 2018 Sep 24;8(1):14268.

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