You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-APA modulator T4
APA modulator T4

Chemical Structure : APA modulator T4

CAS No.: 785708-33-0

APA modulator T4 (Alternative polyadenylation modulator)

Catalog No.: PC-35766Not For Human Use, Lab Use Only.

APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts.

Packing Price Stock Quantity
100 mg Get quote
250 mg Get quote
500 mg Get quote
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts.
APA modulator T4 does not inhibits any of the 404 kinases; predominantly induced CR-APA and UTR-APA.
APA modulator T4 exhibits high potency and selectivity for APA modulation, inducing a preference for the use of proximal intronic poly(A) CSs with long intron regions through the PABPN1 pathway.
APA modulator T4 is a valuable tool for increasing the understanding of the molecular mechanisms of APA and splicing.

Physicochemical Properties

M.Wt 377.444
Formula C22H23N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6,7-dimethoxy2-((4-phenyl-3,6-dihydropyridin-1(2H)-yl)methyl) quinazoline4(3H)-one

References

1. Araki S, et al. Cell Chem Biol. 2018 Sep 26. pii: S2451-9456(18)30301-5.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: