Chemical Structure : APA modulator T4
CAS No.:
785708-33-0
APA modulator T4
(Alternative polyadenylation modulator)
Catalog No.: PC-35766Not For Human Use, Lab Use Only.
APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts.
APA modulator T4 does not inhibits any of the 404 kinases; predominantly induced CR-APA and UTR-APA.
APA modulator T4 exhibits high potency and selectivity for APA modulation, inducing a preference for the use of proximal intronic poly(A) CSs with long intron regions through the PABPN1 pathway.
APA modulator T4 is a valuable tool for increasing the understanding of the molecular mechanisms of APA and splicing.
Physicochemical Properties
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M.Wt
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377.444
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Formula
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C22H23N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6,7-dimethoxy2-((4-phenyl-3,6-dihydropyridin-1(2H)-yl)methyl) quinazoline4(3H)-one
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References
1. Araki S, et al. Cell Chem Biol. 2018 Sep 26. pii: S2451-9456(18)30301-5.
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