Catalog No.: PC-35807Not For Human Use, Lab Use Only.
OGG1 inhibitor O8 is a potent, selective inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 0.22 uM, displays no significant activity against other DNA Glycosylases (NEIL1, NTH1, Fpg, IC50>50 uM).
OGG1 inhibitor O8 is a potent, selective inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 0.22 uM, displays no significant activity against other DNA Glycosylases (NEIL1, NTH1, Fpg, IC50>50 uM).
Physicochemical Properties
M.Wt
261.12
Formula
C9H6Cl2N2OS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
3,4-dichlorobenzo[b]thiophene-2-carbohydrazide
References
1. Donley N, et al. ACS Chem Biol. 2015 Oct 16;10(10):2334-43. doi: 10.1021/acschembio.5b00452.
2. Visnes T, et al. Science. 2018 Nov 16;362(6416):834-839.
