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OGG1 inhibitor O8

Chemical Structure : OGG1 inhibitor O8

CAS No.: 350997-39-6

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OGG1 inhibitor O8 (OGG1 inhibitor 08)

Catalog No.: PC-35807Not For Human Use, Lab Use Only.

OGG1 inhibitor O8 is a potent, selective inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 0.22 uM, displays no significant activity against other DNA Glycosylases (NEIL1, NTH1, Fpg, IC50>50 uM).

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10 mg $88 In stock
25 mg $138 In stock
50 mg $218 In stock
100 mg $368 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

OGG1 inhibitor O8 is a potent, selective inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 0.22 uM, displays no significant activity against other DNA Glycosylases (NEIL1, NTH1, Fpg, IC50>50 uM).

Physicochemical Properties

M.Wt 261.12
Formula C9H6Cl2N2OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3,4-dichlorobenzo[b]thiophene-2-carbohydrazide

References

1. Donley N, et al. ACS Chem Biol. 2015 Oct 16;10(10):2334-43. doi: 10.1021/acschembio.5b00452.

2. Visnes T, et al. Science. 2018 Nov 16;362(6416):834-839.

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