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NEK6 inibitor 8

Chemical Structure : NEK6 inibitor 8

CAS No.: 591239-68-8

NEK6 inibitor 8 (ZINC05007751)

Catalog No.: PC-35735Not For Human Use, Lab Use Only.

NEK6 inibitor 8 (ZINC05007751) is a novel inhibitor of the NIMA-related kinase NEK6 with IC50 of 3.4 uM, compound 8 is very selective against NEK1 and NEK6, while no signifcant activity was observed against NEK2, NEK7, and NEK9.

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Biological Activity

NEK6 inibitor 8 (ZINC05007751) is a novel inhibitor of the NIMA-related kinase NEK6 with IC50 of 3.4 uM, compound 8 is very selective against NEK1 and NEK6, while no signifcant activity was observed against NEK2, NEK7, and NEK9.
NEK6 inibitor 8 dispalys antiproliferative activity against a panel of human cancer cell lines (IC50 <100 uM).

Physicochemical Properties

M.Wt 304.305
Formula C18H12N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile

References

1. De Donato M, et al. Sci Rep. 2018 Oct 30;8(1):16047.

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