| Cat. No. |
Product Name |
Information |
| PC-22333 |
ML257
ABHD10 inhibitor
|
ML257 (ABL303) is a selective inhibitor of α,β-hydrolase domain-containing 10 (ABHD10) with IC50 of 21 nM, >59-fold selectivity over 40+ other serine hydrolases. |
| PC-22304 |
JYQ-173
DJ-1/PARK7 inhibitor
|
JYQ-173 (JYQ173) is a potent, highly selective Parkinson disease protein 7 (PARK7/DJ-1) inhibitor with IC50 of 19 nM, binds covalently and selectively to PARK7 Cys106. |
| PC-22299 |
MTOB sodium
CtBP inhibitor
|
MTOB sodium is a potent C-terminal binding protein (CtBP) inhibitor, inhibits the transactivation activity of CtBP1 and CtBP2. |
| PC-22298 |
CtBP1/BARS inhibitor Comp.11
CtBP1/BARS inhibitor
|
CtBP1/BARS inhibitor Comp.11 is a potent, selective inhibitor targeting the C-terminal-binding protein 1/brefeldin A ADP-ribosylation substrate (CtBP1/BARS), directly binds and inhibits the CtBP1/BARS protein-partners interaction with Kd of 0.66 uM. |
| PC-22285 |
MS-L6
OXPHOS inhibitor
|
MS-L6 is a novel small molecule OXPHOS inhibitor, exerts dual mitochondrial effects: mitochondrial electron transport chain complexe ETC-I inhibition and uncoupling of OXPHOS. |
| PC-22262 |
Fatostatin
SREBP inhibitor
|
Fatostatin (125B11) is a small molecule sterol regulatory element binding protein (SREBP) inhibitor, impairs the activation process of SREBPs, thereby decreasing the transcription of lipogenic genes in cells. |
| PC-22243 |
FeM-1269
Ion mobilizer
|
FeM-1269 is a small molecule ion mobilizer, minimally aggregates and dose-dependently mobilizes iron across lipid bilayers, increases serum iron, transferrin saturation, hemoglobin and hematocrit in mouse model of anemia of inflammation. |
| PC-22240 |
FCW393
Sialyltransferase inhibitor
|
FCW393 is a potent, selective sialyltransferase inhibitor with IC50 of 7.8 uM and 9.48 uM for ST6GAL1 and ST3GAL3, does not inhibit ST3GAL1 and ST8SIA4 (IC50>100 uM), suppresses cancer metastasis. |
| PC-22222 |
Leflunomide
DHODH inhibitor
|
Leflunomide (HWA486, RS-34821, SU101) is a potent dihydroorotate dehydrogenase (DHODH) and pyrimidine synthesis inhibitor with IC50 of 208.5 nM in cell-free human DHODH enzyme inhibition assays. |
| PC-22220 |
HOSU-53 acid
DHODH inhibitor
|
HOSU-53 acid is selective and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 0.95 nM in cell-free human DHODH enzyme inhibition assays. |
| PC-22206 |
UNC-CA2-103
TLK2 inhibitor
|
UNC-CA2-103 is a potent, selective tousled like kinase 2 (TLK2) inhibitor with enzyme IC50 of 18 nM, exhibit excellent selectivity over TLK1 (16% inhibition at 0.5 μM). |
| PC-22184 |
Tacrolimus
FKBP ligand
|
Tacrolimus (FK506) is a macrocyclic lactone that binds to FK506 binding protein (FKBP) to form a complex, inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription, shows immunosuppressive properties. |
