| Cat. No. |
Product Name |
Information |
| PC-35607 |
P053
CerS1 inhibitor
|
P053 (P-053, CerS1 inhibitor P053) is a potent, selective, orally active inhibitor of ceramide synthase 1 (CerS1) with IC50 of 0.5 uM, displays >10-fold selectivity for inhibition of CerS2, CerS4, CerS5, and CerS6. |
| PC-35588 |
CTPI-2
|
CTPI-2 (SLC25A1 inhibitor CTPI-2) is a novel specific SLC25A1 inhibitor with Kd of 3.5 uM, CTPI-2 is synthetic lethal with cisplatin or with EGFR inhibitor co-treatment and restores antitumor responses both in vitro and in vivo. |
| PC-35583 |
NP161
Thioredoxin 1 inhibitor
|
NP161 is a potent and selective inhibitor of extracellular TRX (Thioredoxin 1) in vitro with IC50 of 0.54 uM. |
| PC-35582 |
MFN2 agonist B-A l
MFN2 agonist
|
MFN2 agonist B-A l is a mall-molecule mimics of the peptide-peptide interface of MFN2, allosterically activates MFN2 and promotes mitochondrial fusion with EC50 of 3 nM. |
| PC-35568 |
NGI-1 derivative C-19
OST inhibitor
|
NGI-1 derivative C-19 is a specific, small-molecule inhibitor of oligosaccharyltransferase (OST) catalytic subunit STT3B, without effect on STT3A. |
| PC-35563 |
APX2014
APE1 inhibitor
|
APX2014 (APX-2014) is a novel potent inhibitor of reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease 1 (Ref-1/APE1) with IC50 of 0.2 uM for redox EMSA inhibition. |
| PC-35538 |
AF64394
GPR3 inverse agonist
|
AF64394 is a potent, selective GPR3 inverse agonist with pIC50 of 7.3, displays >100-fold selectivity over GPR6 and GPR12.. |
| PC-35527 |
Qstatin
|
Qstatin is a potent SmcR inhibitor in V. vulnificus. with IC50 of 208.9 nM, shows pan-QS (quorum sensing) inhibitor activity in diverse Vibrio species. |
| PC-35500 |
NMac1
Nm23/NDPK activator
|
NMac1 (Nm23 activator 1) is a small molecule activator of Nm23/NDPK, directly binds to Nm23-H1 and activates NDPK activity of recombinant Nm23-H1 with EC50 of 10.7 uM. |
| PC-35479 |
Padsevonil
|
Padsevonil (UCB0942) is an antiepileptic drug (AED) candidate with high affinity for synaptic vesicle 2 (SV2) proteins with pKi of 8.5/7.9/8.5 for SV2A/SV2B/SV2C, respectively. |
| PC-35466 |
Soticlestat
|
Soticlestat (TAK-935) is a potent, selective, orally active inhibitor for Cholesterol 24-hydroxylase (CH24H) with IC50 of 7.4 nM. |
| PC-35411 |
GAK inhibitor 12r
|
GAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM. |
