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ML250

Chemical Structure : ML250

CAS No.: 1421365-63-0

ML250 (ML 250, CYM50769)

Catalog No.: PC-38611Not For Human Use, Lab Use Only.

ML250 (CYM 50769) is a potent and selective GPR7 (Neuropeptides B/W receptor 1, NPBWR1) antagonist probe, inhibits human GPR7 expression in the presence of GPR7 agonist NPW with IC50 value of 124 nM-244 nM, displays 82- >161 fold selectivity over MCH1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ML250 (CYM 50769) is a potent and selective GPR7 (Neuropeptides B/W receptor 1, NPBWR1) antagonist probe, inhibits human GPR7 expression in the presence of GPR7 agonist NPW with IC50 value of 124 nM-244 nM, displays 82- >161 fold selectivity over MCH1.

Physicochemical Properties

M.Wt 416.861
Formula C24H17ClN2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-chloro-2-(9H-fluoren-9-yl)-4-(4-methoxyphenoxy)pyridazin-3(2H)-one

References

1. Miguel Guerrero, et al. In: Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Miguel Guerrero, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):614-9.

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