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VK-28

Chemical Structure : VK-28

CAS No.: 312611-92-0

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VK-28 (Iron chelator)

Catalog No.: PC-38601Not For Human Use, Lab Use Only.

VK-28 is a novel brain permeable neuroprotective iron chelator with anti-Alzheimer's disease activities, inhibits both basal and Fe/ascorbate-induced mitochondrial membrane lipid peroxidation with IC50 of 12.7 uM.

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1 mg $128 In stock
5 mg $258 In stock
10 mg $428 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VK-28 is a novel brain permeable neuroprotective iron chelator with anti-Alzheimer's disease activities, inhibits both basal and Fe/ascorbate-induced mitochondrial membrane lipid peroxidation with IC50 of 12.7 uM.

Physicochemical Properties

M.Wt 287.363
Formula C16H21N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-[4-(2-Hydroxyethyl)piperazine-1-ylmethyl]-quinoline-8-ol

References

1. Zhu W, et al. FASEB J. 2007 Dec;21(14):3835-44.

2. Bandyopadhyay S, et al. J Neural Transm Suppl. 2006;(71):237-47.

3. Weinreb O, et al. Neurotherapeutics. 2009 Jan;6(1):163-74.

4. Moussa B H Youdim, et al. Mech Ageing Dev. 2005 Feb;126(2):317-26.

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