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FPPS-IN-11

Chemical Structure : FPPS-IN-11

CAS No.: 1250273-31-4

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FPPS-IN-11

Catalog No.: PC-38605Not For Human Use, Lab Use Only.

FPPS-IN-11 is a potent, allosteric, non-bisphosphonate farnesyl pyrophosphate synthase (FPPS) inhibitor with IC50 of 200 nM.

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Biological Activity

FPPS-IN-11 is a potent, allosteric, non-bisphosphonate farnesyl pyrophosphate synthase (FPPS) inhibitor with IC50 of 200 nM.
FPPS-IN-11 displayed similar potencies in biochemical assays to the most potent bisphosphonate, zoledronic acid (IC50=130 nM), and similar to or higher than those of all other bisphosphonates used clinically, such as risedronate, ibandronate, alendronate and pamidronate (IC50 = 150 nM, 340 nM, 850 nM, 950 nM, respectively).

Physicochemical Properties

M.Wt 269.256
Formula C15H11NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(Carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid

References

1. Wolfgang Jahnke, et al. Nat Chem Biol. 2010 Sep;6(9):660-6.

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