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CID 2745687

Chemical Structure : CID 2745687

CAS No.: 264233-05-8

CID 2745687 (CID-2745687)

Catalog No.: PC-38606Not For Human Use, Lab Use Only.

CID-2745687 is a potent, selective and competitive GPR35 antagonist with pIC50 of 6.7 against human GPR35.

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10 mg $188 In stock
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50 mg $528 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CID-2745687 is a potent, selective and competitive GPR35 antagonist with pIC50 of 6.7 against human GPR35.
CID-2745687 competitively inhibited the effects at human GPR35 of cromolyn disodium and zaprinast, two agonists that share an overlapping binding site.
CID-2745687 blocked zaprinast-promoted VSMC migration in the scratch-wound assay.

Physicochemical Properties

M.Wt 395.429
Formula C17H19F2N5O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl-5-[(tert-butylcarbamothioylhydrazinylidene)methyl]-1-(2,4-difluorophenyl)pyrazole-4-carboxylate

References

1. Jenkins L, et al. J Pharmacol Exp Ther. 2012 Dec;343(3):683-95.

2. McCallum JE, et al. J Vasc Res. 2015;52(6):383-95.

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