| Cat. No. |
Product Name |
Information |
| PC-20842 |
GCN2iA
GCN2 inhibitor
|
GCN2iA is a potent seletive inhibitor of general control nonderepressible 2 (GCN2) with IC50 of 4.0 nM. |
| PC-20837 |
SRP-001
Analgesic agent
|
SRP-001 is a non-opioid and non-hepatotoxic small molecule ApAP analog, induces analgesia via N-arachidonoylphenolamine (AM404) formation, and generates higher amounts of AM404 than ApAP. |
| PC-20825 |
eEF-2K inhibitor 2C
eEF-2K inhibitor
|
eEF-2K inhibitor 2C (Compound 2C) is a small molecule inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K), binds to the ATP-binding site of eEF-2K. |
| PC-20817 |
KZR-8445
Sec61 inhibitor
|
KZR-8445 (KZR8445) is a cyclic depsipeptide, client-selective Sec61 inhibitor with IC50 of 100 nM, targets the Sec61 translocon and selectively modulate Sec61-mediated protein biogenesis. |
| PC-20788 |
NSC348884
Nucleophosmin inhibitor
|
NSC348884 is a small molecule nucleophosmin (NPM) inhibitor, disrupts the formation of dimers and inhibits aberrant NPM functionin cancer cells. |
| PC-20785 |
Sodium phytate
|
Sodium phytate (Phytic acid sodium salt, InsP6 sodium) is the most abundant inositol phosphate in cells, is a strong inhibitor of iron absorption from fortified foods, has antioxidant and anti-diabetic properties. |
| PC-20779 |
HP661
OXPHOS inhibitor
|
HP661 is a potent, and selective oral complex I OXPHOS inhibitor with 76% inhibition at 1u M in H460 cells using electron flow assays, inhibits high-OXPHOS H460 cell viability with IC50 of 5 nM. |
| PC-20748 |
Org 214444-0
FSHR agonist
|
Org 214444-0 is a highly potent, selective, allosteric agonist of follicle stimulating hormone receptor (FSHR) with EC50 of 2.0/1.2 nM (human/rat FSHR) in cell-based assays. |
| PC-20719 |
A1120
RBP4 inhibitor
|
A1120 is a high affinity, non-retinoid ligand for retinol-binding protein 4 (RBP4) with Ki of 8.3 nM, disrupts the interaction between RBP4 and its binding partner transthyretin (TTR). |
| PC-20714 |
ME-143
NADH oxidase inhibitor
|
ME-143 (NV-143) is a second-generation tumor-specific NADH oxidase inhibitor, binds to purified recombinant ENOX2 with Kd value of 43 nM, shows broad activity against human cancers in vitro and in vivo. |
| PC-20609 |
SN34960
Perforin inhibitor
|
SN34960 is a small molecule Perforin inhibitor, inhibits perforin-induced lysis of Jurkat T-lymphoma cells with IC50 of 6.65 uM, shows suboptimal physicochemical properties and toxicity toward the natural killer (NK) cells that secrete perforin in vivo. |
| PC-20604 |
Auranofin
TrxR inhibitor, UBA1 enhancer
|
Auranofin (SKF39162) is a specific inhibitor of thioredoxin reductase (TrxR), also is a potent UBA1 E1 ubiquitin-activating enzyme activity enhancer. |
