| Cat. No. |
Product Name |
Information |
| PC-49788 |
DHODH inhibitor M62
DHODH inhibitor
|
DHODH inhibitor M62 is a potent, selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 6.9 nM. |
| PC-49783 |
JNJ-DHODH-IN-29
DHODH inhibitor
|
JNJ-DHODH-IN-29 is a potent, selective DHODH inhibitor with IC50 of 0.3 nM, inhibits MOLM-13 cell proliferation with IC50 of 0.4 nM. |
| PC-49782 |
JNJ-DHODH-IN-19
DHODH inhibitor
|
JNJ-DHODH-IN-19 is a potent, selective DHODH inhibitor with IC50 of 1.1 nM, inhibits MOLM-13 cell proliferation with IC50 of 2.0 nM. |
| PC-49779 |
JNJ-74856665
DHODH inhibitor
|
JNJ74856665 (JNJ74856665) is an orally available, potent and selective DHODH inhibitor with IC50 values in the subnanomolar range. |
| PC-49767 |
CNS-11g
Alpha-synuclein inhibitor
|
CNS-11g is a small molecules capable of disassembling preformed alpha-synuclein fibrils, may exert it's disaggregating effects on the N terminus of the fibril core. |
| PC-49754 |
MM0299
Lanosterol synthase inhibitor
|
MM0299 (MM 0299) is a potent, selective inhibitor of lanosterol synthase (LSS, competition EC50=1.97 nM) with anti-proliferative activity, inhibits Mut6 cell growth (IC50=18.2 nM) and induces the synthesis of 24(S),25-epoxycholesterol (EPC). |
| PC-49750 |
DDAH1 inhibitor 8
DDAH1 inhibitor
|
DDAH1 inhibitor 8 is a potent, selective, nonamino acid, catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1) with Ki of 18 uM, with no significantly affecting NOSs and arginase. |
| PC-49735 |
IM156
OXPHOS inhibitor
|
IM156 (HL156A) is a metformin derivative and potent biguanide OXPHOS inhibitor of Protein Complex 1 (PC1) of the mitochondrial electron transport chain, also shows higher potency of AMPK activation than metformin. |
| PC-49721 |
SBT-272
Cardiolipin stablizer
|
SBT-272 (Bevemipretide) is a brain-penetrant small molecule that stabilizes cardiolipin, a phospholipid found in inner mitochondrial membrane (IMM), thereby restoring mitochondrial structure and respiratory function. |
| PC-49719 |
EPI-589
Oxidoreductase inhibitor
|
EPI-589 (EPI 589) is an orally available, blood-brain barrier permeable redox-active agent characterized by highly potent protective effects against oxidative stress, attenuates oxidative stress due to the radical scavenging activity of the reduced form and affects mitochondrial energy metabolism as a substrate of quinone-oxidoreductases. |
| PC-49692 |
VPS41 inhibitor DMBP
VPS41 inhibitor
|
DMBP is a natural small molecule with preferable anticancer activity, inhibits vacuolar protein sorting-associated protein 41 homolog (VPS41) function, a subunit of the HOPS complex. |
| PC-49677 |
PDS-0330
Claudin-1 inhibitor
|
PDS-0330 (PDS0330) is a first-generation, specific small molecule claudin-1 inhibitor with Kd of 22.9 uM in MST binding assays, impairs the interaction between claudin1 and pSrc/Src and alters survival signaling pathways. |
