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Chemical Structure : GPR31 antagonist SAH2
Catalog No.: PC-21741Not For Human Use, Lab Use Only.
GPR31 antagonist SAH2 (SLU-0011371) is the first highly potent and selective small molecule GPR31 antagonist, antagonizes 12(S)-HETE-induced β-arrestin recruitment with IC50 of 1.09 uM.
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GPR31 antagonist SAH2 (SLU-0011371) is the first highly potent and selective small molecule GPR31 antagonist, antagonizes 12(S)-HETE-induced β-arrestin recruitment with IC50 of 1.09 uM.
GPR31 antagonist SAH2 (SLU-0011371) binds to hydrophobic pocket and its carboxylic acid can interact with R98 in transmembrane domain (TM) 3 and R242 in TM5.
SAH2 (10 mg/kg, intrathecal injection) reverse CCI-induced behavioral hypersensitivities in male and female mice.
| M.Wt | 403.52 | |
| Formula | C23H33NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Giancotti LA, et al. J Pharmacol Exp Ther. 2024 Jan 26:JPET-AR-2023-001853.
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